Injectable In Situ Forming Depot Systems for Long-Acting Contraception

Dileep R. Janagam, Suryatheja Ananthula, Kamaljit Chaudhry, Linfeng Wu, Timothy D. Mandrell, James R. Johnson, Tao Lowe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Up to date, no long-acting reversible contraceptive (LARC) is developed to be injectable through needles smaller than 18 G and can also provide contraception for more than 3 months after single injection. In this study, injectable polymeric in situ forming depot (ISD) systems are developed to have injectability through 21–23 G needles, and capability of sustained release of levonorgestrel (LNG) for at least 7 months in vitro and in vivo after single subcutaneous injection in rats. The systems are polymeric solutions composed of biodegradable poly(lactide-co-glycolide) and poly(lactic acid) polymers dissolved in a mixture of solvents like N-methyl-2-pyrrolidone and benzyl benzoate or triethyl citrate. LNG released from ISD systems successfully suppressed the estrous cycle of rats at plasma concentration above 0.35 ng mL −1 . At the end of the treatment, when LNG plasma concentration drops down to be nondetectable, predictable return of fertility is observed in rats. The designed ISD systems have great potential to be further developed into robust injectable LARCs that can be injected through a 21 G or smaller needle and achieve a variety of contraception durations with high patient compliance and low cost.

Original languageEnglish (US)
Article number1700097
JournalAdvanced Biosystems
Volume1
Issue number10
DOIs
StatePublished - Oct 1 2017

Fingerprint

Levonorgestrel
Contraception
Needles
Rats
Injections
Plasmas
Polyglactin 910
Lactic acid
Contraceptive Agents
Estrous Cycle
Polymers
Subcutaneous Injections
Patient Compliance
Fertility
Costs and Cost Analysis
Costs
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biomaterials
  • Biomedical Engineering

Cite this

Janagam, D. R., Ananthula, S., Chaudhry, K., Wu, L., Mandrell, T. D., Johnson, J. R., & Lowe, T. (2017). Injectable In Situ Forming Depot Systems for Long-Acting Contraception. Advanced Biosystems, 1(10), [1700097]. https://doi.org/10.1002/adbi.201700097

Injectable In Situ Forming Depot Systems for Long-Acting Contraception. / Janagam, Dileep R.; Ananthula, Suryatheja; Chaudhry, Kamaljit; Wu, Linfeng; Mandrell, Timothy D.; Johnson, James R.; Lowe, Tao.

In: Advanced Biosystems, Vol. 1, No. 10, 1700097, 01.10.2017.

Research output: Contribution to journalArticle

Janagam, DR, Ananthula, S, Chaudhry, K, Wu, L, Mandrell, TD, Johnson, JR & Lowe, T 2017, 'Injectable In Situ Forming Depot Systems for Long-Acting Contraception', Advanced Biosystems, vol. 1, no. 10, 1700097. https://doi.org/10.1002/adbi.201700097
Janagam DR, Ananthula S, Chaudhry K, Wu L, Mandrell TD, Johnson JR et al. Injectable In Situ Forming Depot Systems for Long-Acting Contraception. Advanced Biosystems. 2017 Oct 1;1(10). 1700097. https://doi.org/10.1002/adbi.201700097
Janagam, Dileep R. ; Ananthula, Suryatheja ; Chaudhry, Kamaljit ; Wu, Linfeng ; Mandrell, Timothy D. ; Johnson, James R. ; Lowe, Tao. / Injectable In Situ Forming Depot Systems for Long-Acting Contraception. In: Advanced Biosystems. 2017 ; Vol. 1, No. 10.
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