Injection of SCH 23390, but not 7-hydroxy-DPAT, into the ventral tegmental area blocks the acute motor-stimulant response to cocaine

Jeffery Steketee, B. C. Braswell

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The present studies examined the effects of intra-ventral tegmental area (VTA) injection of SCH 23390, a dopamine (DA) D1 receptor antagonist or 7-OH-DPAT, a DA D2/3 receptor agonist, on cocaine-stimulated motor activity. Intra-VTA SCH 23390 (1.5-15 nmol/side) dose-dependently blocked cocaine-induced motor activity. Thus, 15 nmol/side SCH 23390 completely blocked, while 5 nmol/side attenuated, the motor-stimulant response to cocaine. These doses of SCH 23390 did not alter basal motor activity, suggesting the effects on the motor-stimulant response to cocaine were not the result of a generalized suppression of activity. In contrast to previous studies, intra-VTA 7-OH-DPAT did not alter basal motor activity at any of the doses tested (0.5-15 nmol/side). In addition, intra-VTA 7-OH-DPAT (1.5-15 nmol/side) pretreatment did not significantly alter the motor-stimulant response to cocaine. These data suggest that DA D1 receptors in the VTA may play a role in psychostimulant-induced motor activity, However, the role DA D2/3 receptors in the VTA may have in cocaine-induced motor activity remains unclear.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalBehavioural Pharmacology
Volume8
Issue number1
StatePublished - 1997
Externally publishedYes

Fingerprint

Ventral Tegmental Area
Cocaine
Motor Activity
Injections
Dopamine D1 Receptors
Dopamine D2 Receptors
Dopamine Antagonists
SCH 23390
7-hydroxy-2-N,N-dipropylaminotetralin
hydroxide ion

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Pharmacology

Cite this

@article{dcae9e8d83674679b5e72d529c045693,
title = "Injection of SCH 23390, but not 7-hydroxy-DPAT, into the ventral tegmental area blocks the acute motor-stimulant response to cocaine",
abstract = "The present studies examined the effects of intra-ventral tegmental area (VTA) injection of SCH 23390, a dopamine (DA) D1 receptor antagonist or 7-OH-DPAT, a DA D2/3 receptor agonist, on cocaine-stimulated motor activity. Intra-VTA SCH 23390 (1.5-15 nmol/side) dose-dependently blocked cocaine-induced motor activity. Thus, 15 nmol/side SCH 23390 completely blocked, while 5 nmol/side attenuated, the motor-stimulant response to cocaine. These doses of SCH 23390 did not alter basal motor activity, suggesting the effects on the motor-stimulant response to cocaine were not the result of a generalized suppression of activity. In contrast to previous studies, intra-VTA 7-OH-DPAT did not alter basal motor activity at any of the doses tested (0.5-15 nmol/side). In addition, intra-VTA 7-OH-DPAT (1.5-15 nmol/side) pretreatment did not significantly alter the motor-stimulant response to cocaine. These data suggest that DA D1 receptors in the VTA may play a role in psychostimulant-induced motor activity, However, the role DA D2/3 receptors in the VTA may have in cocaine-induced motor activity remains unclear.",
author = "Jeffery Steketee and Braswell, {B. C.}",
year = "1997",
language = "English (US)",
volume = "8",
pages = "58--64",
journal = "Behavioural Pharmacology",
issn = "0955-8810",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Injection of SCH 23390, but not 7-hydroxy-DPAT, into the ventral tegmental area blocks the acute motor-stimulant response to cocaine

AU - Steketee, Jeffery

AU - Braswell, B. C.

PY - 1997

Y1 - 1997

N2 - The present studies examined the effects of intra-ventral tegmental area (VTA) injection of SCH 23390, a dopamine (DA) D1 receptor antagonist or 7-OH-DPAT, a DA D2/3 receptor agonist, on cocaine-stimulated motor activity. Intra-VTA SCH 23390 (1.5-15 nmol/side) dose-dependently blocked cocaine-induced motor activity. Thus, 15 nmol/side SCH 23390 completely blocked, while 5 nmol/side attenuated, the motor-stimulant response to cocaine. These doses of SCH 23390 did not alter basal motor activity, suggesting the effects on the motor-stimulant response to cocaine were not the result of a generalized suppression of activity. In contrast to previous studies, intra-VTA 7-OH-DPAT did not alter basal motor activity at any of the doses tested (0.5-15 nmol/side). In addition, intra-VTA 7-OH-DPAT (1.5-15 nmol/side) pretreatment did not significantly alter the motor-stimulant response to cocaine. These data suggest that DA D1 receptors in the VTA may play a role in psychostimulant-induced motor activity, However, the role DA D2/3 receptors in the VTA may have in cocaine-induced motor activity remains unclear.

AB - The present studies examined the effects of intra-ventral tegmental area (VTA) injection of SCH 23390, a dopamine (DA) D1 receptor antagonist or 7-OH-DPAT, a DA D2/3 receptor agonist, on cocaine-stimulated motor activity. Intra-VTA SCH 23390 (1.5-15 nmol/side) dose-dependently blocked cocaine-induced motor activity. Thus, 15 nmol/side SCH 23390 completely blocked, while 5 nmol/side attenuated, the motor-stimulant response to cocaine. These doses of SCH 23390 did not alter basal motor activity, suggesting the effects on the motor-stimulant response to cocaine were not the result of a generalized suppression of activity. In contrast to previous studies, intra-VTA 7-OH-DPAT did not alter basal motor activity at any of the doses tested (0.5-15 nmol/side). In addition, intra-VTA 7-OH-DPAT (1.5-15 nmol/side) pretreatment did not significantly alter the motor-stimulant response to cocaine. These data suggest that DA D1 receptors in the VTA may play a role in psychostimulant-induced motor activity, However, the role DA D2/3 receptors in the VTA may have in cocaine-induced motor activity remains unclear.

UR - http://www.scopus.com/inward/record.url?scp=0030996947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030996947&partnerID=8YFLogxK

M3 - Article

C2 - 9833001

AN - SCOPUS:0030996947

VL - 8

SP - 58

EP - 64

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

SN - 0955-8810

IS - 1

ER -