Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex

Daisuke Nakayama, Tomohiro Matsuyama, Hatsue Ishibashi-Ueda, Takayuki Nakagomi, Yukiko Kasahara, Haruka Hirose, Akie Kikuchi-Taura, David Stern, Hidezo Mori, Akihiko Taguchi

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Increasing evidence points to accelerated neurogenesis after stroke, and support of such endogenous neurogenesis has been shown to improve stroke outcome in experimental animal models. The present study analyses post-stroke cerebral cortex after cardiogenic embolism in autoptic human brain. Induction of nestin- and musashi-1-positive cells, potential neural stem/progenitor cells, was observed at the site of ischemic lesions from day 1 after stroke. These two cell populations were present at distinct locations and displayed different temporal profiles of marker expression. However, no surviving differentiated mature neural cells were observed by 90 days after stroke in the previously ischemic region. Consistent with recent reports of neurogenesis in the cerebral cortex after induction of stroke in rodent models, the present current data indicate the presence of a regional regenerative response in human cerebral cortex. Furthermore, observations underline the potential importance of supporting survival and differentiation of endogenous neural stem/progenitor cells in post-stroke human brain.

Original languageEnglish (US)
Pages (from-to)90-98
Number of pages9
JournalEuropean Journal of Neuroscience
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

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Neural Stem Cells
Cerebral Cortex
Stem Cells
Stroke
Wounds and Injuries
Neurogenesis
Nestin
Brain
Embolism
Rodentia
Animal Models
Survival
Population

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nakayama, D., Matsuyama, T., Ishibashi-Ueda, H., Nakagomi, T., Kasahara, Y., Hirose, H., ... Taguchi, A. (2010). Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex. European Journal of Neuroscience, 31(1), 90-98. https://doi.org/10.1111/j.1460-9568.2009.07043.x

Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex. / Nakayama, Daisuke; Matsuyama, Tomohiro; Ishibashi-Ueda, Hatsue; Nakagomi, Takayuki; Kasahara, Yukiko; Hirose, Haruka; Kikuchi-Taura, Akie; Stern, David; Mori, Hidezo; Taguchi, Akihiko.

In: European Journal of Neuroscience, Vol. 31, No. 1, 01.01.2010, p. 90-98.

Research output: Contribution to journalArticle

Nakayama, D, Matsuyama, T, Ishibashi-Ueda, H, Nakagomi, T, Kasahara, Y, Hirose, H, Kikuchi-Taura, A, Stern, D, Mori, H & Taguchi, A 2010, 'Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex', European Journal of Neuroscience, vol. 31, no. 1, pp. 90-98. https://doi.org/10.1111/j.1460-9568.2009.07043.x
Nakayama D, Matsuyama T, Ishibashi-Ueda H, Nakagomi T, Kasahara Y, Hirose H et al. Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex. European Journal of Neuroscience. 2010 Jan 1;31(1):90-98. https://doi.org/10.1111/j.1460-9568.2009.07043.x
Nakayama, Daisuke ; Matsuyama, Tomohiro ; Ishibashi-Ueda, Hatsue ; Nakagomi, Takayuki ; Kasahara, Yukiko ; Hirose, Haruka ; Kikuchi-Taura, Akie ; Stern, David ; Mori, Hidezo ; Taguchi, Akihiko. / Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex. In: European Journal of Neuroscience. 2010 ; Vol. 31, No. 1. pp. 90-98.
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