Innate immune responses in hepatitis C virus infection

Kui Li, Stanley M. Lemon

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) is a major causative agent of chronic hepatitis and hepatocellular carcinoma worldwide and thus poses a significant public health threat. A hallmark of HCV infection is the extraordinary ability of the virus to persist in a majority of infected people. Innate immune responses represent the front line of defense of the human body against HCV immediately after infection. They also play a crucial role in orchestrating subsequent HCV-specific adaptive immunity that is pivotal for viral clearance. Accumulating evidence suggests that the host has evolved multifaceted innate immune mechanisms to sense HCV infection and elicit defense responses, while HCV has developed elaborate strategies to circumvent many of these. Defining the interplay of HCV with host innate immunity reveals mechanistic insights into hepatitis C pathogenesis and informs approaches to therapy. In this review, we summarize recent advances in understanding innate immune responses to HCV infection, focusing on induction and effector mechanisms of the interferon antiviral response as well as the evasion strategies of HCV.

Original languageEnglish (US)
Pages (from-to)53-72
Number of pages20
JournalSeminars in Immunopathology
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Virus Diseases
Innate Immunity
Hepacivirus
Adaptive Immunity
Chronic Hepatitis
Hepatitis C
Human Body
Interferons
Antiviral Agents
Hepatocellular Carcinoma
Public Health
Viruses
Infection

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Innate immune responses in hepatitis C virus infection. / Li, Kui; Lemon, Stanley M.

In: Seminars in Immunopathology, Vol. 35, No. 1, 01.01.2013, p. 53-72.

Research output: Contribution to journalReview article

Li, Kui ; Lemon, Stanley M. / Innate immune responses in hepatitis C virus infection. In: Seminars in Immunopathology. 2013 ; Vol. 35, No. 1. pp. 53-72.
@article{03c500a1bb85467bac8e9618b601323b,
title = "Innate immune responses in hepatitis C virus infection",
abstract = "Hepatitis C virus (HCV) is a major causative agent of chronic hepatitis and hepatocellular carcinoma worldwide and thus poses a significant public health threat. A hallmark of HCV infection is the extraordinary ability of the virus to persist in a majority of infected people. Innate immune responses represent the front line of defense of the human body against HCV immediately after infection. They also play a crucial role in orchestrating subsequent HCV-specific adaptive immunity that is pivotal for viral clearance. Accumulating evidence suggests that the host has evolved multifaceted innate immune mechanisms to sense HCV infection and elicit defense responses, while HCV has developed elaborate strategies to circumvent many of these. Defining the interplay of HCV with host innate immunity reveals mechanistic insights into hepatitis C pathogenesis and informs approaches to therapy. In this review, we summarize recent advances in understanding innate immune responses to HCV infection, focusing on induction and effector mechanisms of the interferon antiviral response as well as the evasion strategies of HCV.",
author = "Kui Li and Lemon, {Stanley M.}",
year = "2013",
month = "1",
day = "1",
doi = "10.1007/s00281-012-0332-x",
language = "English (US)",
volume = "35",
pages = "53--72",
journal = "Seminars in Immunopathology",
issn = "1863-2297",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Innate immune responses in hepatitis C virus infection

AU - Li, Kui

AU - Lemon, Stanley M.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Hepatitis C virus (HCV) is a major causative agent of chronic hepatitis and hepatocellular carcinoma worldwide and thus poses a significant public health threat. A hallmark of HCV infection is the extraordinary ability of the virus to persist in a majority of infected people. Innate immune responses represent the front line of defense of the human body against HCV immediately after infection. They also play a crucial role in orchestrating subsequent HCV-specific adaptive immunity that is pivotal for viral clearance. Accumulating evidence suggests that the host has evolved multifaceted innate immune mechanisms to sense HCV infection and elicit defense responses, while HCV has developed elaborate strategies to circumvent many of these. Defining the interplay of HCV with host innate immunity reveals mechanistic insights into hepatitis C pathogenesis and informs approaches to therapy. In this review, we summarize recent advances in understanding innate immune responses to HCV infection, focusing on induction and effector mechanisms of the interferon antiviral response as well as the evasion strategies of HCV.

AB - Hepatitis C virus (HCV) is a major causative agent of chronic hepatitis and hepatocellular carcinoma worldwide and thus poses a significant public health threat. A hallmark of HCV infection is the extraordinary ability of the virus to persist in a majority of infected people. Innate immune responses represent the front line of defense of the human body against HCV immediately after infection. They also play a crucial role in orchestrating subsequent HCV-specific adaptive immunity that is pivotal for viral clearance. Accumulating evidence suggests that the host has evolved multifaceted innate immune mechanisms to sense HCV infection and elicit defense responses, while HCV has developed elaborate strategies to circumvent many of these. Defining the interplay of HCV with host innate immunity reveals mechanistic insights into hepatitis C pathogenesis and informs approaches to therapy. In this review, we summarize recent advances in understanding innate immune responses to HCV infection, focusing on induction and effector mechanisms of the interferon antiviral response as well as the evasion strategies of HCV.

UR - http://www.scopus.com/inward/record.url?scp=84872396542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872396542&partnerID=8YFLogxK

U2 - 10.1007/s00281-012-0332-x

DO - 10.1007/s00281-012-0332-x

M3 - Review article

VL - 35

SP - 53

EP - 72

JO - Seminars in Immunopathology

JF - Seminars in Immunopathology

SN - 1863-2297

IS - 1

ER -