Inositol trisphosphate receptors in smooth muscle cells

Damodaran Narayanan, Adebowale Adebiyi, Jonathan Jaggar

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Inositol 1,4,5-trisphosphate receptors (IP 3Rs) are a family of tetrameric intracellular calcium (Ca 2+) release channels that are located on the sarcoplasmic reticulum (SR) membrane of virtually all mammalian cell types, including smooth muscle cells (SMC). Here, we have reviewed literature investigating IP 3R expression, cellular localization, tissue distribution, activity regulation, communication with ion channels and organelles, generation of Ca 2+ signals, modulation of physiological functions, and alterations in pathologies in SMCs. Three IP 3R isoforms have been identified, with relative expression and cellular localization of each contributing to signaling differences in diverse SMC types. Several endogenous ligands, kinases, proteins, and other modulators control SMC IP 3R channel activity. SMC IP 3Rs communicate with nearby ryanodine-sensitive Ca 2+ channels and mitochondria to influence SR Ca 2+ release and reactive oxygen species generation. IP 3R-mediated Ca 2+ release can stimulate plasma membrane-localized channels, including transient receptor potential (TRP) channels and store-operated Ca 2+ channels. SMC IP 3Rs also signal to other proteins via SR Ca 2+ release-independent mechanisms through physical coupling to TRP channels and local communication with large-conductance Ca 2+activated potassium channels. IP 3R-mediated Ca 2+ release generates a wide variety of intracellular Ca 2+ signals, which vary with respect to frequency, amplitude, spatial, and temporal properties. IP 3R signaling controls multiple SMC functions, including contraction, gene expression, migration, and proliferation. IP 3R expression and cellular signaling are altered in several SMC diseases, notably asthma, atherosclerosis, diabetes, and hypertension. In summary, IP 3R-mediated pathways control diverse SMC physiological functions, with pathological alterations in IP 3R signaling contributing to disease.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume302
Issue number11
DOIs
StatePublished - Jun 1 2012

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Inositol
Smooth Muscle Myocytes
Sarcoplasmic Reticulum
Transient Receptor Potential Channels
Ion Channels
Inositol 1,4,5-Trisphosphate Receptors
Ryanodine
Potassium Channels
Tissue Distribution
Organelles
Reactive Oxygen Species
Atherosclerosis
Mitochondria
Protein Isoforms
Asthma
Cell Membrane
Pathology
Ligands
Hypertension
Calcium

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Inositol trisphosphate receptors in smooth muscle cells. / Narayanan, Damodaran; Adebiyi, Adebowale; Jaggar, Jonathan.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 302, No. 11, 01.06.2012.

Research output: Contribution to journalReview article

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