Instances of mantle cell lymphoma morphologically mimicking other subtypes of B-cell lymphoid proliferation

Maurice J. Schuetz, Nadeem Zafar, Mohammad A. Vasef

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Mantle cell lymphoma is a well-characterized category of mature B-cell lymphoma with aberrant coexpression of CD5 antigen. This subtype of lymphoma is genetically defined by t(11;14) resulting in upregulation of cyclin D1 protein. In clinical practice, mantle cell lymphoma is typically diagnosed based on combination of morphology, CD20/CD5 coexpression, and nuclear staining of cyclin D1 protein by immunohistochemistry. Although other neoplastic processes can also be cyclin D1 positive, documentation of cyclin D1 positivity in a CD5-positive B-cell process is virtually diagnostic of mantle cell lymphoma. However, on morphologic grounds, it is well known that mantle cell lymphoma can mimic other subtypes of B-cell lymphoid neoplasm. We identified several unusual examples of immunohistochemically confirmed cyclin D1-positive mantle cell lymphoma with morphologic features overlapping with a wide variety of other subtypes of mature B-cell lymphomas including follicular, marginal zone, small lymphocytic and Burkitt lymphoma.

Original languageEnglish (US)
Pages (from-to)369-373
Number of pages5
JournalSouthern medical journal
Volume102
Issue number4
DOIs
StatePublished - Apr 1 2009

Fingerprint

Mantle-Cell Lymphoma
Cyclin D1
B-Lymphocytes
Cell Proliferation
B-Cell Lymphoma
CD5 Antigens
Neoplastic Processes
Burkitt Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Documentation
Lymphoma
Proteins
Up-Regulation
Immunohistochemistry
Staining and Labeling
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Instances of mantle cell lymphoma morphologically mimicking other subtypes of B-cell lymphoid proliferation. / Schuetz, Maurice J.; Zafar, Nadeem; Vasef, Mohammad A.

In: Southern medical journal, Vol. 102, No. 4, 01.04.2009, p. 369-373.

Research output: Contribution to journalArticle

Schuetz, Maurice J. ; Zafar, Nadeem ; Vasef, Mohammad A. / Instances of mantle cell lymphoma morphologically mimicking other subtypes of B-cell lymphoid proliferation. In: Southern medical journal. 2009 ; Vol. 102, No. 4. pp. 369-373.
@article{b9dd714602a94c8ea8e70b1f74558462,
title = "Instances of mantle cell lymphoma morphologically mimicking other subtypes of B-cell lymphoid proliferation",
abstract = "Mantle cell lymphoma is a well-characterized category of mature B-cell lymphoma with aberrant coexpression of CD5 antigen. This subtype of lymphoma is genetically defined by t(11;14) resulting in upregulation of cyclin D1 protein. In clinical practice, mantle cell lymphoma is typically diagnosed based on combination of morphology, CD20/CD5 coexpression, and nuclear staining of cyclin D1 protein by immunohistochemistry. Although other neoplastic processes can also be cyclin D1 positive, documentation of cyclin D1 positivity in a CD5-positive B-cell process is virtually diagnostic of mantle cell lymphoma. However, on morphologic grounds, it is well known that mantle cell lymphoma can mimic other subtypes of B-cell lymphoid neoplasm. We identified several unusual examples of immunohistochemically confirmed cyclin D1-positive mantle cell lymphoma with morphologic features overlapping with a wide variety of other subtypes of mature B-cell lymphomas including follicular, marginal zone, small lymphocytic and Burkitt lymphoma.",
author = "Schuetz, {Maurice J.} and Nadeem Zafar and Vasef, {Mohammad A.}",
year = "2009",
month = "4",
day = "1",
doi = "10.1097/SMJ.0b013e31819b6cb7",
language = "English (US)",
volume = "102",
pages = "369--373",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Instances of mantle cell lymphoma morphologically mimicking other subtypes of B-cell lymphoid proliferation

AU - Schuetz, Maurice J.

AU - Zafar, Nadeem

AU - Vasef, Mohammad A.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Mantle cell lymphoma is a well-characterized category of mature B-cell lymphoma with aberrant coexpression of CD5 antigen. This subtype of lymphoma is genetically defined by t(11;14) resulting in upregulation of cyclin D1 protein. In clinical practice, mantle cell lymphoma is typically diagnosed based on combination of morphology, CD20/CD5 coexpression, and nuclear staining of cyclin D1 protein by immunohistochemistry. Although other neoplastic processes can also be cyclin D1 positive, documentation of cyclin D1 positivity in a CD5-positive B-cell process is virtually diagnostic of mantle cell lymphoma. However, on morphologic grounds, it is well known that mantle cell lymphoma can mimic other subtypes of B-cell lymphoid neoplasm. We identified several unusual examples of immunohistochemically confirmed cyclin D1-positive mantle cell lymphoma with morphologic features overlapping with a wide variety of other subtypes of mature B-cell lymphomas including follicular, marginal zone, small lymphocytic and Burkitt lymphoma.

AB - Mantle cell lymphoma is a well-characterized category of mature B-cell lymphoma with aberrant coexpression of CD5 antigen. This subtype of lymphoma is genetically defined by t(11;14) resulting in upregulation of cyclin D1 protein. In clinical practice, mantle cell lymphoma is typically diagnosed based on combination of morphology, CD20/CD5 coexpression, and nuclear staining of cyclin D1 protein by immunohistochemistry. Although other neoplastic processes can also be cyclin D1 positive, documentation of cyclin D1 positivity in a CD5-positive B-cell process is virtually diagnostic of mantle cell lymphoma. However, on morphologic grounds, it is well known that mantle cell lymphoma can mimic other subtypes of B-cell lymphoid neoplasm. We identified several unusual examples of immunohistochemically confirmed cyclin D1-positive mantle cell lymphoma with morphologic features overlapping with a wide variety of other subtypes of mature B-cell lymphomas including follicular, marginal zone, small lymphocytic and Burkitt lymphoma.

UR - http://www.scopus.com/inward/record.url?scp=67651176026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651176026&partnerID=8YFLogxK

U2 - 10.1097/SMJ.0b013e31819b6cb7

DO - 10.1097/SMJ.0b013e31819b6cb7

M3 - Article

VL - 102

SP - 369

EP - 373

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 4

ER -