Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations

Efthimios Dardiotis, Vasileios Siokas, Tilemachos Zafeiridis, Konstantinos Paterakis, Georgios Tsivgoulis, Maria Dardioti, Savas Grigoriadis, Constantina Simeonidou, Georgia Deretzi, Elias Zintzaras, Jeremiasz Jagiella, Georgios M. Hadjigeorgiou

Research output: Contribution to journalArticle

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Abstract

Α limited number of genetic variants have been linked to the development of intracerebral hemorrhage (ICH). Ιntegrin AV and/or B8-deficient mice were found to develop ICH. The present candidate gene association study was designed to investigate possible influence of integrin AV (ITGAV) and integrin B8 (ITGB8) gene region polymorphisms on the risk of ICH. 1015 participants (250 Greek and 193 Polish patients with primary ICH and 250 Greek and 322 Polish controls) were included in the study. Using logistic regression analyses, 11 tag single nucleotide polymorphisms (SNPs) for ITGAV and 11 for ITGB8 gene were tested for associations with ICH risk, lobar ICH risk and non-lobar ICH after adjustment for age, gender, history of hypertension and country of origin. Linear regression models were used to test the effect of tag SNPs on the ICH age of onset. Correction for multiple comparisons was carried out. The rs7565633 tag SNP of the ITGAV gene was independently associated with the risk of lobar ICH in the codominant model of inheritance [odds ratio (95 % confidence interval (CI)) 0.56 (0.36–0.86), p = 0.0013]. Furthermore, heterozygous individuals of the rs10251386 and the rs10239099 of the ITGB8 gene had significantly lower age of ICH onset compared to the wild-type genotypes [regression coefficient (b) −3.884 (95 % CI −6.519, −1.249), p = 0.0039 and b = −4.502 (95 % CI −7.159, −1.845), p = 0.0009, respectively]. The present study provides preliminary indication for an influence of ITGAV gene tag SNP in the development of lobar ICH and of ITGB8 gene variants in the age of ICH onset.

Original languageEnglish (US)
Pages (from-to)69-80
Number of pages12
JournalNeuroMolecular Medicine
Volume19
Issue number1
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

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Cerebral Hemorrhage
Integrins
Population
Genes
Single Nucleotide Polymorphism
Confidence Intervals
Linear Models
Genetic Association Studies
Age of Onset
Logistic Models
Odds Ratio
Genotype
Regression Analysis
Hypertension

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations. / Dardiotis, Efthimios; Siokas, Vasileios; Zafeiridis, Tilemachos; Paterakis, Konstantinos; Tsivgoulis, Georgios; Dardioti, Maria; Grigoriadis, Savas; Simeonidou, Constantina; Deretzi, Georgia; Zintzaras, Elias; Jagiella, Jeremiasz; Hadjigeorgiou, Georgios M.

In: NeuroMolecular Medicine, Vol. 19, No. 1, 01.03.2017, p. 69-80.

Research output: Contribution to journalArticle

Dardiotis, E, Siokas, V, Zafeiridis, T, Paterakis, K, Tsivgoulis, G, Dardioti, M, Grigoriadis, S, Simeonidou, C, Deretzi, G, Zintzaras, E, Jagiella, J & Hadjigeorgiou, GM 2017, 'Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations', NeuroMolecular Medicine, vol. 19, no. 1, pp. 69-80. https://doi.org/10.1007/s12017-016-8429-3
Dardiotis, Efthimios ; Siokas, Vasileios ; Zafeiridis, Tilemachos ; Paterakis, Konstantinos ; Tsivgoulis, Georgios ; Dardioti, Maria ; Grigoriadis, Savas ; Simeonidou, Constantina ; Deretzi, Georgia ; Zintzaras, Elias ; Jagiella, Jeremiasz ; Hadjigeorgiou, Georgios M. / Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations. In: NeuroMolecular Medicine. 2017 ; Vol. 19, No. 1. pp. 69-80.
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abstract = "Α limited number of genetic variants have been linked to the development of intracerebral hemorrhage (ICH). Ιntegrin AV and/or B8-deficient mice were found to develop ICH. The present candidate gene association study was designed to investigate possible influence of integrin AV (ITGAV) and integrin B8 (ITGB8) gene region polymorphisms on the risk of ICH. 1015 participants (250 Greek and 193 Polish patients with primary ICH and 250 Greek and 322 Polish controls) were included in the study. Using logistic regression analyses, 11 tag single nucleotide polymorphisms (SNPs) for ITGAV and 11 for ITGB8 gene were tested for associations with ICH risk, lobar ICH risk and non-lobar ICH after adjustment for age, gender, history of hypertension and country of origin. Linear regression models were used to test the effect of tag SNPs on the ICH age of onset. Correction for multiple comparisons was carried out. The rs7565633 tag SNP of the ITGAV gene was independently associated with the risk of lobar ICH in the codominant model of inheritance [odds ratio (95 {\%} confidence interval (CI)) 0.56 (0.36–0.86), p = 0.0013]. Furthermore, heterozygous individuals of the rs10251386 and the rs10239099 of the ITGB8 gene had significantly lower age of ICH onset compared to the wild-type genotypes [regression coefficient (b) −3.884 (95 {\%} CI −6.519, −1.249), p = 0.0039 and b = −4.502 (95 {\%} CI −7.159, −1.845), p = 0.0009, respectively]. The present study provides preliminary indication for an influence of ITGAV gene tag SNP in the development of lobar ICH and of ITGB8 gene variants in the age of ICH onset.",
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AU - Paterakis, Konstantinos

AU - Tsivgoulis, Georgios

AU - Dardioti, Maria

AU - Grigoriadis, Savas

AU - Simeonidou, Constantina

AU - Deretzi, Georgia

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