Intensive blood pressure control during the hyperacute phase of intracerebral hemorrhage in patients at risk for resistant hypertension

A retrospective cohort study

Kerry M. Mohrien, Lucas Elijovich, Garrett T. Venable, Douglas R. Taylor, G. Morgan Jones

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: There are limited data evaluating intensive systolic blood pressure (SBP) control during the hyperacute phase of intracerebral hemorrhage (ICH) in patients with multiple risk factors for resistant hypertension. We evaluated the feasibility and safety of this intervention in a primary population that includes patients with multiple risk factors for resistant hypertension. Materials and methods: We conducted a retrospective analysis of ICH patients for which intensive SBP control (<. 140 mm Hg)- i.e. less than or equal to 140 was targeted. All patients possessed at least 2 risk factors that have been associated with resistant hypertension. Our primary objective was to determine the percentage of patients who achieved goal SBP within 1 hour of ICH diagnosis. Secondary objectives included identifying predictors of achieving goal SBP within 6 hours. Results: Goal SBP within 1 hour was achieved in 8.1% of patients. The total number of risk factors a patient possessed was found to negatively predict ability to achieve goal SBP. For each risk factor possessed, the odds of achieving goal SBP within 6 hours are reduced by 31% (odds ratio, 0.69 [95% confidence interval, 0.54-0.89]). Conclusion: Intensive SBP control after ICH was difficult to achieve within 1 hour in those with risk factors for resistant hypertension. Patients' total risk factors were found to reduce the odds of achieving goal SBP within 6 hours.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalJournal of Critical Care
Volume30
Issue number2
DOIs
StatePublished - Apr 1 2015

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Cerebral Hemorrhage
Cohort Studies
Retrospective Studies
Blood Pressure
Hypertension

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

Intensive blood pressure control during the hyperacute phase of intracerebral hemorrhage in patients at risk for resistant hypertension : A retrospective cohort study. / Mohrien, Kerry M.; Elijovich, Lucas; Venable, Garrett T.; Taylor, Douglas R.; Jones, G. Morgan.

In: Journal of Critical Care, Vol. 30, No. 2, 01.04.2015, p. 369-374.

Research output: Contribution to journalArticle

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