Intentional weight loss and endometrial cancer risk

Juhua Luo, Rowan T. Chlebowski, Michael Hendryx, Thomas Rohan, Jean Wactawski-Wende, Cynthia A. Thomson, Ashley S. Felix, Chu Chen, Wendy Barrington, Mathilda Coday, Marcia Stefanick, Erin LeBlanc, Karen L. Margolis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose Although obesity is an established endometrial cancer risk factor, information about the influence of weight loss on endometrial cancer risk in postmenopausal women is limited. Therefore, we evaluated associations among weight change by intentionality with endometrial cancer in the Women's Health Initiative (WHI) observational study. Patients and Methods Postmenopausal women (N = 36,794) ages 50 to 79 years at WHI enrollment had their body weights measured and body mass indices calculated at baseline and at year 3. Weight change during that period was categorized as follows: stable (change within ± 5%), loss (change ≥ 5%), and gain (change ≥ 5%). Weight loss intentionality was assessed via self-report at year 3; change was characterized as intentional or unintentional. During the subsequent 11.4 years (mean) of follow-up, 566 incident endometrial cancer occurrences were confirmed by medical record review. Multivariable Cox proportional hazards regression models were used to evaluate relationships (hazard ratios [HRs] and 95% CIs) between weight change and endometrial cancer incidence. Results In multivariable analyses, compared with women who had stable weight (± 5%), women with weight loss had a significantly lower endometrial cancer risk (HR, 0.71; 95% CI, 0.54 to 0.95). The association was strongest among obese women with intentional weight loss (HR, 0.44; 95% CI, 0.25 to 0.78). Weight gain (≥ 10 pounds) was associated with a higher endometrial cancer risk than was stable weight, especially among women who had never used hormones. Conclusion Intentional weight loss in postmenopausal women is associated with a lower endometrial cancer risk, especially among women with obesity. These findings should motivate programs for weight loss in obese postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1189-1193
Number of pages5
JournalJournal of Clinical Oncology
Volume35
Issue number11
DOIs
StatePublished - Apr 10 2017

Fingerprint

Endometrial Neoplasms
Weight Loss
Weights and Measures
Women's Health
Obesity
Weight Reduction Programs
Proportional Hazards Models
Self Report
Weight Gain
Medical Records
Observational Studies
Body Mass Index
Odds Ratio
Body Weight
Hormones
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Luo, J., Chlebowski, R. T., Hendryx, M., Rohan, T., Wactawski-Wende, J., Thomson, C. A., ... Margolis, K. L. (2017). Intentional weight loss and endometrial cancer risk. Journal of Clinical Oncology, 35(11), 1189-1193. https://doi.org/10.1200/JCO.2016.70.5822

Intentional weight loss and endometrial cancer risk. / Luo, Juhua; Chlebowski, Rowan T.; Hendryx, Michael; Rohan, Thomas; Wactawski-Wende, Jean; Thomson, Cynthia A.; Felix, Ashley S.; Chen, Chu; Barrington, Wendy; Coday, Mathilda; Stefanick, Marcia; LeBlanc, Erin; Margolis, Karen L.

In: Journal of Clinical Oncology, Vol. 35, No. 11, 10.04.2017, p. 1189-1193.

Research output: Contribution to journalArticle

Luo, J, Chlebowski, RT, Hendryx, M, Rohan, T, Wactawski-Wende, J, Thomson, CA, Felix, AS, Chen, C, Barrington, W, Coday, M, Stefanick, M, LeBlanc, E & Margolis, KL 2017, 'Intentional weight loss and endometrial cancer risk', Journal of Clinical Oncology, vol. 35, no. 11, pp. 1189-1193. https://doi.org/10.1200/JCO.2016.70.5822
Luo J, Chlebowski RT, Hendryx M, Rohan T, Wactawski-Wende J, Thomson CA et al. Intentional weight loss and endometrial cancer risk. Journal of Clinical Oncology. 2017 Apr 10;35(11):1189-1193. https://doi.org/10.1200/JCO.2016.70.5822
Luo, Juhua ; Chlebowski, Rowan T. ; Hendryx, Michael ; Rohan, Thomas ; Wactawski-Wende, Jean ; Thomson, Cynthia A. ; Felix, Ashley S. ; Chen, Chu ; Barrington, Wendy ; Coday, Mathilda ; Stefanick, Marcia ; LeBlanc, Erin ; Margolis, Karen L. / Intentional weight loss and endometrial cancer risk. In: Journal of Clinical Oncology. 2017 ; Vol. 35, No. 11. pp. 1189-1193.
@article{d1ffd7f6c2d54a888dd8c2c17dd4f847,
title = "Intentional weight loss and endometrial cancer risk",
abstract = "Purpose Although obesity is an established endometrial cancer risk factor, information about the influence of weight loss on endometrial cancer risk in postmenopausal women is limited. Therefore, we evaluated associations among weight change by intentionality with endometrial cancer in the Women's Health Initiative (WHI) observational study. Patients and Methods Postmenopausal women (N = 36,794) ages 50 to 79 years at WHI enrollment had their body weights measured and body mass indices calculated at baseline and at year 3. Weight change during that period was categorized as follows: stable (change within ± 5{\%}), loss (change ≥ 5{\%}), and gain (change ≥ 5{\%}). Weight loss intentionality was assessed via self-report at year 3; change was characterized as intentional or unintentional. During the subsequent 11.4 years (mean) of follow-up, 566 incident endometrial cancer occurrences were confirmed by medical record review. Multivariable Cox proportional hazards regression models were used to evaluate relationships (hazard ratios [HRs] and 95{\%} CIs) between weight change and endometrial cancer incidence. Results In multivariable analyses, compared with women who had stable weight (± 5{\%}), women with weight loss had a significantly lower endometrial cancer risk (HR, 0.71; 95{\%} CI, 0.54 to 0.95). The association was strongest among obese women with intentional weight loss (HR, 0.44; 95{\%} CI, 0.25 to 0.78). Weight gain (≥ 10 pounds) was associated with a higher endometrial cancer risk than was stable weight, especially among women who had never used hormones. Conclusion Intentional weight loss in postmenopausal women is associated with a lower endometrial cancer risk, especially among women with obesity. These findings should motivate programs for weight loss in obese postmenopausal women.",
author = "Juhua Luo and Chlebowski, {Rowan T.} and Michael Hendryx and Thomas Rohan and Jean Wactawski-Wende and Thomson, {Cynthia A.} and Felix, {Ashley S.} and Chu Chen and Wendy Barrington and Mathilda Coday and Marcia Stefanick and Erin LeBlanc and Margolis, {Karen L.}",
year = "2017",
month = "4",
day = "10",
doi = "10.1200/JCO.2016.70.5822",
language = "English (US)",
volume = "35",
pages = "1189--1193",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "11",

}

TY - JOUR

T1 - Intentional weight loss and endometrial cancer risk

AU - Luo, Juhua

AU - Chlebowski, Rowan T.

AU - Hendryx, Michael

AU - Rohan, Thomas

AU - Wactawski-Wende, Jean

AU - Thomson, Cynthia A.

AU - Felix, Ashley S.

AU - Chen, Chu

AU - Barrington, Wendy

AU - Coday, Mathilda

AU - Stefanick, Marcia

AU - LeBlanc, Erin

AU - Margolis, Karen L.

PY - 2017/4/10

Y1 - 2017/4/10

N2 - Purpose Although obesity is an established endometrial cancer risk factor, information about the influence of weight loss on endometrial cancer risk in postmenopausal women is limited. Therefore, we evaluated associations among weight change by intentionality with endometrial cancer in the Women's Health Initiative (WHI) observational study. Patients and Methods Postmenopausal women (N = 36,794) ages 50 to 79 years at WHI enrollment had their body weights measured and body mass indices calculated at baseline and at year 3. Weight change during that period was categorized as follows: stable (change within ± 5%), loss (change ≥ 5%), and gain (change ≥ 5%). Weight loss intentionality was assessed via self-report at year 3; change was characterized as intentional or unintentional. During the subsequent 11.4 years (mean) of follow-up, 566 incident endometrial cancer occurrences were confirmed by medical record review. Multivariable Cox proportional hazards regression models were used to evaluate relationships (hazard ratios [HRs] and 95% CIs) between weight change and endometrial cancer incidence. Results In multivariable analyses, compared with women who had stable weight (± 5%), women with weight loss had a significantly lower endometrial cancer risk (HR, 0.71; 95% CI, 0.54 to 0.95). The association was strongest among obese women with intentional weight loss (HR, 0.44; 95% CI, 0.25 to 0.78). Weight gain (≥ 10 pounds) was associated with a higher endometrial cancer risk than was stable weight, especially among women who had never used hormones. Conclusion Intentional weight loss in postmenopausal women is associated with a lower endometrial cancer risk, especially among women with obesity. These findings should motivate programs for weight loss in obese postmenopausal women.

AB - Purpose Although obesity is an established endometrial cancer risk factor, information about the influence of weight loss on endometrial cancer risk in postmenopausal women is limited. Therefore, we evaluated associations among weight change by intentionality with endometrial cancer in the Women's Health Initiative (WHI) observational study. Patients and Methods Postmenopausal women (N = 36,794) ages 50 to 79 years at WHI enrollment had their body weights measured and body mass indices calculated at baseline and at year 3. Weight change during that period was categorized as follows: stable (change within ± 5%), loss (change ≥ 5%), and gain (change ≥ 5%). Weight loss intentionality was assessed via self-report at year 3; change was characterized as intentional or unintentional. During the subsequent 11.4 years (mean) of follow-up, 566 incident endometrial cancer occurrences were confirmed by medical record review. Multivariable Cox proportional hazards regression models were used to evaluate relationships (hazard ratios [HRs] and 95% CIs) between weight change and endometrial cancer incidence. Results In multivariable analyses, compared with women who had stable weight (± 5%), women with weight loss had a significantly lower endometrial cancer risk (HR, 0.71; 95% CI, 0.54 to 0.95). The association was strongest among obese women with intentional weight loss (HR, 0.44; 95% CI, 0.25 to 0.78). Weight gain (≥ 10 pounds) was associated with a higher endometrial cancer risk than was stable weight, especially among women who had never used hormones. Conclusion Intentional weight loss in postmenopausal women is associated with a lower endometrial cancer risk, especially among women with obesity. These findings should motivate programs for weight loss in obese postmenopausal women.

UR - http://www.scopus.com/inward/record.url?scp=85017313335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017313335&partnerID=8YFLogxK

U2 - 10.1200/JCO.2016.70.5822

DO - 10.1200/JCO.2016.70.5822

M3 - Article

VL - 35

SP - 1189

EP - 1193

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 11

ER -