Interaction between rifampin and levothyroxine

Steven R. Nolan, Timothy H. Self, John M. Norwood

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Rifampin is a potent inducer of hepatic enzymes and is well documented to cause many clinically significant drug interactions. Studies in normal volunteers have shown its ability to decrease circulating levels of thyroid hormone, while having no effect on thyroid-stimulating hormone (TSH). Reports of rifampin's effects on patients on hormone replacement in the clinical setting are of interest since we believe only one such case has been described. We report the case of a man, stable on levothyroxine, who exhibited significantly elevated TSH levels during therapy with rifampin. Thyroid-stimulating hormone levels returned to baseline 9 days after discontinuance of rifampin.

Original languageEnglish (US)
Pages (from-to)529-531
Number of pages3
JournalSouthern Medical Journal
Volume92
Issue number5
DOIs
StatePublished - May 1999

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Rifampin
Thyroxine
Thyrotropin
Thyroid Hormones
Drug Interactions
Healthy Volunteers
Hormones
Liver
Enzymes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Interaction between rifampin and levothyroxine. / Nolan, Steven R.; Self, Timothy H.; Norwood, John M.

In: Southern Medical Journal, Vol. 92, No. 5, 05.1999, p. 529-531.

Research output: Contribution to journalArticle

Nolan, Steven R. ; Self, Timothy H. ; Norwood, John M. / Interaction between rifampin and levothyroxine. In: Southern Medical Journal. 1999 ; Vol. 92, No. 5. pp. 529-531.
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