Interaction of vitamin-K-dependent coagulation factors and the endothelium

Peter P. Nawroth, David Stern

Research output: Contribution to journalEditorial

Abstract

Local regulation of blood coagulation is a central issue in thrombosis and hemostasis, as the cells forming the luminal vascular surface endothelial cells are ideally situated to play an important role in determining the outcome of coagulant reactions. Endothelial cells can express specific binding sites for vitamin-K-dependent coagulation factors. Binding to these may lead to changes in substrate specificity, internalization, degradation and regulation of coagulation. Evidence is provided that suggests regulation of receptor expression by cytokines as interleukin 1 or tumor necrosis factor plays a key role in maintenance of free blood flow or thrombus formation.

Original languageEnglish (US)
Pages (from-to)117-119
Number of pages3
JournalCardiovascular Drugs and Therapy
Volume3
Issue number2
DOIs
StatePublished - Mar 1 1989
Externally publishedYes

Fingerprint

Blood Coagulation Factors
Vitamin K
Endothelium
Thrombosis
Endothelial Cells
Coagulants
Cytokine Receptors
Blood Coagulation
Substrate Specificity
Hemostasis
Interleukin-1
Tumor Necrosis Factor-alpha
Binding Sites
Maintenance

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Interaction of vitamin-K-dependent coagulation factors and the endothelium. / Nawroth, Peter P.; Stern, David.

In: Cardiovascular Drugs and Therapy, Vol. 3, No. 2, 01.03.1989, p. 117-119.

Research output: Contribution to journalEditorial

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