Interethnic differences in beta-2 adrenoceptor (BAR2) polymorphisms in African-American (AA), Caucasian (CA), and Chinese (CHN) populations

H. G. Xie, R. B. Kim, C. M. Stein, J. V. Gainer, N. J. Brown, B. Leake, Zhousheng Xiao, N. He, H. H. Zhou, A. J.J. Wood

Research output: Contribution to journalArticle

Abstract

There are marked interethnic differences in BAR2-mediated vascular response. To determine if racial differences exist in the distribution of BAR2 polymorphisms, three healthy populations consisting of 104 CHN, 123 AA, and 188 CA subjects were studied. A PCR-based SSCP method with direct sequencing of the bands of interest was used for detection of the two common BAR2 variants (Arg16→Gly and Gln27→Glu). CHN had a significantly lower frequency of the Gly 16 allele (41.3%) than AA (51.2%, P=0.04) or CA (54.3%, P=0.003), a lower frequency of the Gly 16 homozygotes than CA (18.3% vs 35.1%, P=0.003), and a lower frequency of the Glu27 allele (7.2%) than AA (20.7%, P<0.0001) or CA (34.8%, P<0.0001). AA had a lower frequency of the Glu27 allele (20.7% vs 34.8%, P<0.0001) and Glu27 homozygotes (4.9% vs 15.4%, P=0.003) than CA. These data suggest that responses to BAR2 stimulation in different ethnic populations may vary on the basis of genetic factors.

Original languageEnglish (US)
Number of pages1
JournalClinical Pharmacology and Therapeutics
Volume65
Issue number2
DOIs
StatePublished - Jan 1 1999

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African Americans
Adrenergic Receptors
Homozygote
Gene Frequency
Population
Single-Stranded Conformational Polymorphism
Blood Vessels
Alleles
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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Interethnic differences in beta-2 adrenoceptor (BAR2) polymorphisms in African-American (AA), Caucasian (CA), and Chinese (CHN) populations. / Xie, H. G.; Kim, R. B.; Stein, C. M.; Gainer, J. V.; Brown, N. J.; Leake, B.; Xiao, Zhousheng; He, N.; Zhou, H. H.; Wood, A. J.J.

In: Clinical Pharmacology and Therapeutics, Vol. 65, No. 2, 01.01.1999.

Research output: Contribution to journalArticle

Xie, H. G. ; Kim, R. B. ; Stein, C. M. ; Gainer, J. V. ; Brown, N. J. ; Leake, B. ; Xiao, Zhousheng ; He, N. ; Zhou, H. H. ; Wood, A. J.J. / Interethnic differences in beta-2 adrenoceptor (BAR2) polymorphisms in African-American (AA), Caucasian (CA), and Chinese (CHN) populations. In: Clinical Pharmacology and Therapeutics. 1999 ; Vol. 65, No. 2.
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abstract = "There are marked interethnic differences in BAR2-mediated vascular response. To determine if racial differences exist in the distribution of BAR2 polymorphisms, three healthy populations consisting of 104 CHN, 123 AA, and 188 CA subjects were studied. A PCR-based SSCP method with direct sequencing of the bands of interest was used for detection of the two common BAR2 variants (Arg16→Gly and Gln27→Glu). CHN had a significantly lower frequency of the Gly 16 allele (41.3{\%}) than AA (51.2{\%}, P=0.04) or CA (54.3{\%}, P=0.003), a lower frequency of the Gly 16 homozygotes than CA (18.3{\%} vs 35.1{\%}, P=0.003), and a lower frequency of the Glu27 allele (7.2{\%}) than AA (20.7{\%}, P<0.0001) or CA (34.8{\%}, P<0.0001). AA had a lower frequency of the Glu27 allele (20.7{\%} vs 34.8{\%}, P<0.0001) and Glu27 homozygotes (4.9{\%} vs 15.4{\%}, P=0.003) than CA. These data suggest that responses to BAR2 stimulation in different ethnic populations may vary on the basis of genetic factors.",
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