Interferon-β Inhibition of Concanavalin A-Stimulated Calcium Uptake and Exchange in HeLa Cells

Lawrence Pfeffer, Igor Tamm

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Addition of the lectin concanavalin A (ConA) to HeLa-S3 tumor cells in culture stimulates calcium exchange and uptake. Pretreatment of the cells with interferon-β (IFN-β) at a concentration of 640 U/ml for 24 h markedly inhibits this ConA-stimulated calcium exchange and uptake, but not the basal level of calcium exchange. These findings suggest that a number of IFN effects on cell function may reflect an impaired ability of IFN-treated cells to respond to molecules such as growth factors and peptide hormones with increased calcium fluxes.

Original languageEnglish (US)
Pages (from-to)551-556
Number of pages6
JournalJournal of Interferon Research
Volume6
Issue number5
DOIs
StatePublished - Jan 1 1986

Fingerprint

Concanavalin A
HeLa Cells
Interferons
Calcium
Peptide Hormones
Lectins
Growth Hormone
Intercellular Signaling Peptides and Proteins
Cell Culture Techniques
Neoplasms

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology

Cite this

Interferon-β Inhibition of Concanavalin A-Stimulated Calcium Uptake and Exchange in HeLa Cells. / Pfeffer, Lawrence; Tamm, Igor.

In: Journal of Interferon Research, Vol. 6, No. 5, 01.01.1986, p. 551-556.

Research output: Contribution to journalArticle

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