Interferon inhibits the redistribution of cell surface components

Lawrence Pfeffer, E. Wang, I. Tamm

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Interferon treatment impairs the ability of cells to redistribute cell surface receptors for concanavalin A (Con A). The effect of interferon becomes evident within 3-6 h and is maximal within 36-48 h. Highly purified human fibroblast interferon (>2x10 8 U/mg of protein sp act; concentration: 640 U/ml) caused ~85% inhibition of capping of fluorescein-conjugated Con A in interferon-sensitive HeLa-S3 cells at 36 h from the beginning of treatment.

Original languageEnglish (US)
Pages (from-to)469-474
Number of pages6
JournalJournal of Experimental Medicine
Volume152
Issue number2
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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Cellular Structures
Interferons
Concanavalin A
Interferon-beta
Cell Surface Receptors
Fluorescein
HeLa Cells
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Interferon inhibits the redistribution of cell surface components. / Pfeffer, Lawrence; Wang, E.; Tamm, I.

In: Journal of Experimental Medicine, Vol. 152, No. 2, 01.01.1980, p. 469-474.

Research output: Contribution to journalArticle

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