Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly

Sheida Malekpour, Zhimin li, Bing Leung Patrick Cheung, Eduardo M. Castillo, Andrew C. Papanicolaou, Larry A. Kramer, Jack M. Fletcher, Barry D. Van Veen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The impact of the posterior callosal anomalies associated with spina bifida on interhemispheric cortical connectivity is studied using a method for estimating cortical multivariable autoregressive models from scalp magnetoencephalography data. Interhemispheric effective and functional connectivity, measured using conditional Granger causality and coherence, respectively, is determined for the anterior and posterior cortical regions in a population of five spina bifida and five control subjects during a resting eyes-closed state. The estimated connectivity is shown to be consistent over the randomly selected subsets of the data for each subject. The posterior interhemispheric effective and functional connectivity and cortical power are significantly lower in the spina bifida group, a result that is consistent with posterior callosal anomalies. The anterior interhemispheric effective and functional connectivity are elevated in the spina bifida group, a result that may reflect compensatory mechanisms. In contrast, the intrahemispheric effective connectivity is comparable in the two groups. The differences between the spina bifida and control groups are most significant in the θ and α bands.

Original languageEnglish (US)
Pages (from-to)142-154
Number of pages13
JournalBrain Connectivity
Volume2
Issue number3
DOIs
StatePublished - Jun 1 2012

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Spinal Dysraphism
Corpus Callosum
Magnetoencephalography
Scalp
Causality
Control Groups
Population

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Malekpour, S., li, Z., Cheung, B. L. P., Castillo, E. M., Papanicolaou, A. C., Kramer, L. A., ... Van Veen, B. D. (2012). Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly. Brain Connectivity, 2(3), 142-154. https://doi.org/10.1089/brain.2011.0058

Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly. / Malekpour, Sheida; li, Zhimin; Cheung, Bing Leung Patrick; Castillo, Eduardo M.; Papanicolaou, Andrew C.; Kramer, Larry A.; Fletcher, Jack M.; Van Veen, Barry D.

In: Brain Connectivity, Vol. 2, No. 3, 01.06.2012, p. 142-154.

Research output: Contribution to journalArticle

Malekpour, S, li, Z, Cheung, BLP, Castillo, EM, Papanicolaou, AC, Kramer, LA, Fletcher, JM & Van Veen, BD 2012, 'Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly', Brain Connectivity, vol. 2, no. 3, pp. 142-154. https://doi.org/10.1089/brain.2011.0058
Malekpour, Sheida ; li, Zhimin ; Cheung, Bing Leung Patrick ; Castillo, Eduardo M. ; Papanicolaou, Andrew C. ; Kramer, Larry A. ; Fletcher, Jack M. ; Van Veen, Barry D. / Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly. In: Brain Connectivity. 2012 ; Vol. 2, No. 3. pp. 142-154.
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