Interleukin-6 (IL6) Genotype Is Associated with Fat-Free Mass in Men but Not Women

Stephen M. Roth, Matthew A. Schrager, Mechele R. Lee, E. Metter, Ben F. Hurley, Robert E. Ferrell

Research output: Contribution to journalArticle

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Abstract

We studied the association of the G-174C promoter polymorphism in the interleukin-6 gene (IL6) with total body fat and fat-free mass (FFM) in 242 men and women (IL6 genotypes: G/G, n = 87; G/C, n = 100; C/C, n = 55) across the adult age span (21-92 years). In men, but not women (significant genotype by sex interactions; p = .023-.048), the C/C group exhibited significantly lower total FFM than the G/G group (54.7 ± 0.8 kg vs 57.2 ± 0.7 kg, respectively, p = .020), as well as significantly lower FFM of the lower limbs compared with the G/G group (18.4 ± 0.3 kg vs 19.8 ± 0.3 kg, respectively, p = .004). No significant genotype differences were observed in total body fat mass in either men or women. The results indicate that the IL6 G-174C polymorphism is significantly associated with FFM in men but not women.

Original languageEnglish (US)
Pages (from-to)1085-1088
Number of pages4
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume58
Issue number12
StatePublished - Dec 2003
Externally publishedYes

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Interleukin-6
Fats
Genotype
Adipose Tissue
Lower Extremity
Genes

All Science Journal Classification (ASJC) codes

  • Aging

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Interleukin-6 (IL6) Genotype Is Associated with Fat-Free Mass in Men but Not Women. / Roth, Stephen M.; Schrager, Matthew A.; Lee, Mechele R.; Metter, E.; Hurley, Ben F.; Ferrell, Robert E.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 58, No. 12, 12.2003, p. 1085-1088.

Research output: Contribution to journalArticle

Roth, Stephen M. ; Schrager, Matthew A. ; Lee, Mechele R. ; Metter, E. ; Hurley, Ben F. ; Ferrell, Robert E. / Interleukin-6 (IL6) Genotype Is Associated with Fat-Free Mass in Men but Not Women. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2003 ; Vol. 58, No. 12. pp. 1085-1088.
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