Intermittent and continuous ceftazidime infusion for critically ill trauma patients

Scott D. Hanes, G Christopher Wood, Vanessa Herring, Martin Croce, Timothy Fabian, Elizabeth Pritchard, Bradley Boucher

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Background: The adequacy of intermittent and continuous infusion ceftazidime for the treatment of nosocomial pneumonia in critically ill trauma patients was assessed by analyzing ceftazidime pharmacokinetics in relation to the minimum inhibitory concentration (MIC) and treatment outcome. Methods: Serial blood samples were obtained during ceftazidime therapy in 31 trauma patients. Ceftazidime pharmacokinetics were compared with that of previously studied healthy volunteers. Ceftazidime pharmacokinetics were analyzed according to the time above the MIC and treatment outcome. Results: Critically ill trauma patients had a significantly increased volume of distribution and clearance (0.32 ± 0.14 L/kg and 2.35 ± 0.89 mL · min-1 · kg-1, respectively) compared with healthy volunteers (0.21 ± 0.03 and 1.58 ± 0.23 mL · min-1 · kg-1). The time above the MIC was ≥92% of the dosing interval for all patients and treatment outcomes were similar between the two treatment groups. Conclusions: Ceftazidime pharmacokinetics are significantly altered in critically ill trauma patients. Both intermittent and continuous ceftazidime regimens were equally effective for the treatment of nosocomial pneumonia caused by less virulent bacteria. (C) 2000 by Excerpta Medica, Inc.

Original languageEnglish (US)
Pages (from-to)436-440
Number of pages5
JournalAmerican Journal of Surgery
Volume179
Issue number6
DOIs
StatePublished - Jun 1 2000

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Ceftazidime
Critical Illness
Wounds and Injuries
Microbial Sensitivity Tests
Pharmacokinetics
Pneumonia
Healthy Volunteers
Therapeutics
Bacteria

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Intermittent and continuous ceftazidime infusion for critically ill trauma patients. / Hanes, Scott D.; Wood, G Christopher; Herring, Vanessa; Croce, Martin; Fabian, Timothy; Pritchard, Elizabeth; Boucher, Bradley.

In: American Journal of Surgery, Vol. 179, No. 6, 01.06.2000, p. 436-440.

Research output: Contribution to journalArticle

Hanes, Scott D. ; Wood, G Christopher ; Herring, Vanessa ; Croce, Martin ; Fabian, Timothy ; Pritchard, Elizabeth ; Boucher, Bradley. / Intermittent and continuous ceftazidime infusion for critically ill trauma patients. In: American Journal of Surgery. 2000 ; Vol. 179, No. 6. pp. 436-440.
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AU - Pritchard, Elizabeth

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