International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature

Jerold Chun, Edward J. Goetzl, Timothy Hla, Yasuyuki Igarashi, Kevin R. Lynch, Wouter Moolenaar, Susan Pyne, Gabor Tigyi

Research output: Contribution to journalReview article

425 Citations (Scopus)

Abstract

The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are now recognized as important extracellular signaling molecules. These lipid mediators are pleiotropic; among the most common cellular responses are mitogenesis, cell survival (anti-apoptosis), inhibition of adenylyl cyclase and calcium mobilization. Physiologic events associated with these mediators include platelet aggregation, vasopressor activity, wound healing, immune modulation, and angiogenesis. Many of the actions of LPA and S1P are mediated through a set of eight G protein-coupled receptors. Five of these are S1P-prefering while the remaining three are LPA receptors. These receptors are expressed widely and in aggregate signal through a variety of heterotrimeric G proteins. The lysophospholipid receptor family is referred to commonly as the "Edg" group (e.g., Edg-1, Edg-2, etc.). Herein, the molecular pharmacology of the lysophospholipid receptors is reviewed briefly, and a rational nomenclature for LPA and S1P receptors that is consistent with the International Union of Pharmacology guidelines is proposed.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalPharmacological Reviews
Volume54
Issue number2
DOIs
StatePublished - Jan 1 2002

Fingerprint

Lysophospholipid Receptors
Terminology
Pharmacology
Lysophosphatidic Acid Receptors
Lysosphingolipid Receptors
Lysophospholipids
Heterotrimeric GTP-Binding Proteins
G-Protein-Coupled Receptors
Platelet Aggregation
Adenylyl Cyclases
Wound Healing
Cell Survival
Guidelines
Apoptosis
Calcium
Lipids
sphingosine 1-phosphate
lysophosphatidic acid

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Chun, J., Goetzl, E. J., Hla, T., Igarashi, Y., Lynch, K. R., Moolenaar, W., ... Tigyi, G. (2002). International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews, 54(2), 265-269. https://doi.org/10.1124/pr.54.2.265

International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. / Chun, Jerold; Goetzl, Edward J.; Hla, Timothy; Igarashi, Yasuyuki; Lynch, Kevin R.; Moolenaar, Wouter; Pyne, Susan; Tigyi, Gabor.

In: Pharmacological Reviews, Vol. 54, No. 2, 01.01.2002, p. 265-269.

Research output: Contribution to journalReview article

Chun, J, Goetzl, EJ, Hla, T, Igarashi, Y, Lynch, KR, Moolenaar, W, Pyne, S & Tigyi, G 2002, 'International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature', Pharmacological Reviews, vol. 54, no. 2, pp. 265-269. https://doi.org/10.1124/pr.54.2.265
Chun J, Goetzl EJ, Hla T, Igarashi Y, Lynch KR, Moolenaar W et al. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews. 2002 Jan 1;54(2):265-269. https://doi.org/10.1124/pr.54.2.265
Chun, Jerold ; Goetzl, Edward J. ; Hla, Timothy ; Igarashi, Yasuyuki ; Lynch, Kevin R. ; Moolenaar, Wouter ; Pyne, Susan ; Tigyi, Gabor. / International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. In: Pharmacological Reviews. 2002 ; Vol. 54, No. 2. pp. 265-269.
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