Interneurons in the rat striatum

relationships between parvalbumin neurons and cholinergic neurons

H. T. Chang, Hitoshi Kita

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

A pre-embedding double-labeling immunocytochemical method was used to examine the synatic relationships between cholinergic neurons and the parvalbumin immunoreactive (PV+) neurons. The PV+ neurons were labeled by silver-intensified colloidal gold particles, and the cholinergic neurons by immunoperoxidase reaction products. Cholinergic and PV+ axon terminals form synapses with both the somata and dendrites of PV+ neurons, as well as unlabeled medium-sized somata with round un-indented nuclei, a typical characteristic of the medium spiny projection neurons. These observations suggest that the PV+ and the cholinergic neurons have converging influences on both the projection neurons and the PV+ interneurons in the striatum.

Original languageEnglish (US)
Pages (from-to)307-311
Number of pages5
JournalBrain Research
Volume574
Issue number1-2
DOIs
StatePublished - Mar 6 1992

Fingerprint

Parvalbumins
Cholinergic Neurons
Interneurons
Neurons
Carisoprodol
Gold Colloid
Presynaptic Terminals
Dendrites
Silver
Synapses
Cholinergic Agents

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Interneurons in the rat striatum : relationships between parvalbumin neurons and cholinergic neurons. / Chang, H. T.; Kita, Hitoshi.

In: Brain Research, Vol. 574, No. 1-2, 06.03.1992, p. 307-311.

Research output: Contribution to journalArticle

@article{b8f05ddeaba64453b6779b717ed9743e,
title = "Interneurons in the rat striatum: relationships between parvalbumin neurons and cholinergic neurons",
abstract = "A pre-embedding double-labeling immunocytochemical method was used to examine the synatic relationships between cholinergic neurons and the parvalbumin immunoreactive (PV+) neurons. The PV+ neurons were labeled by silver-intensified colloidal gold particles, and the cholinergic neurons by immunoperoxidase reaction products. Cholinergic and PV+ axon terminals form synapses with both the somata and dendrites of PV+ neurons, as well as unlabeled medium-sized somata with round un-indented nuclei, a typical characteristic of the medium spiny projection neurons. These observations suggest that the PV+ and the cholinergic neurons have converging influences on both the projection neurons and the PV+ interneurons in the striatum.",
author = "Chang, {H. T.} and Hitoshi Kita",
year = "1992",
month = "3",
day = "6",
doi = "10.1016/0006-8993(92)90830-3",
language = "English (US)",
volume = "574",
pages = "307--311",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Interneurons in the rat striatum

T2 - relationships between parvalbumin neurons and cholinergic neurons

AU - Chang, H. T.

AU - Kita, Hitoshi

PY - 1992/3/6

Y1 - 1992/3/6

N2 - A pre-embedding double-labeling immunocytochemical method was used to examine the synatic relationships between cholinergic neurons and the parvalbumin immunoreactive (PV+) neurons. The PV+ neurons were labeled by silver-intensified colloidal gold particles, and the cholinergic neurons by immunoperoxidase reaction products. Cholinergic and PV+ axon terminals form synapses with both the somata and dendrites of PV+ neurons, as well as unlabeled medium-sized somata with round un-indented nuclei, a typical characteristic of the medium spiny projection neurons. These observations suggest that the PV+ and the cholinergic neurons have converging influences on both the projection neurons and the PV+ interneurons in the striatum.

AB - A pre-embedding double-labeling immunocytochemical method was used to examine the synatic relationships between cholinergic neurons and the parvalbumin immunoreactive (PV+) neurons. The PV+ neurons were labeled by silver-intensified colloidal gold particles, and the cholinergic neurons by immunoperoxidase reaction products. Cholinergic and PV+ axon terminals form synapses with both the somata and dendrites of PV+ neurons, as well as unlabeled medium-sized somata with round un-indented nuclei, a typical characteristic of the medium spiny projection neurons. These observations suggest that the PV+ and the cholinergic neurons have converging influences on both the projection neurons and the PV+ interneurons in the striatum.

UR - http://www.scopus.com/inward/record.url?scp=0026529470&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026529470&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(92)90830-3

DO - 10.1016/0006-8993(92)90830-3

M3 - Article

VL - 574

SP - 307

EP - 311

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -