Interrelationship of thermal and sleep-wakefulness changes elicited from the medial preoptic area in rats

Subimal Datta, V. Mohan Kumar, G. S. Chhina, B. Singh

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The study investigated the possible interrelationship between changes in sleep-wakefulness and body temperature, primarily induced by manipulation of the noradrenergic system in the medial preoptic area. Saline, norepinephrine, and its α- and β-blockers were injected in the medial preoptic area and in some control areas of rats, during their sleeping and active periods. 5-Hydroxytryptamine was injected in the medial preoptic area in another group of animals. Simultaneous changes in sleep-wakefulness and the body temperature were continuously recorded. Norepinephrine produced hypothermia and arousal, whereas α-adrenergic blockers induced hyperthermia and sleep. These changes in body temperature and in sleep-wakefulness did not follow an identical time course. 5-Hydroxytryptamine induced hyperthermia without affecting sleep-wakefulness. It is suggested that there are different neuronal mechanisms in the medial preoptic area that bring about the drug-induced changes in temperature and sleep-wakefulness.

Original languageEnglish (US)
Pages (from-to)40-50
Number of pages11
JournalExperimental Neurology
Volume100
Issue number1
DOIs
StatePublished - Jan 1 1988

Fingerprint

Preoptic Area
Wakefulness
Sleep
Hot Temperature
Induced Hyperthermia
Body Temperature
Serotonin
Norepinephrine
Body Temperature Changes
Adrenergic Antagonists
Arousal
Hypothermia
Temperature
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology

Cite this

Interrelationship of thermal and sleep-wakefulness changes elicited from the medial preoptic area in rats. / Datta, Subimal; Kumar, V. Mohan; Chhina, G. S.; Singh, B.

In: Experimental Neurology, Vol. 100, No. 1, 01.01.1988, p. 40-50.

Research output: Contribution to journalArticle

@article{d794e117727e46d0bb67ae6d4d409f72,
title = "Interrelationship of thermal and sleep-wakefulness changes elicited from the medial preoptic area in rats",
abstract = "The study investigated the possible interrelationship between changes in sleep-wakefulness and body temperature, primarily induced by manipulation of the noradrenergic system in the medial preoptic area. Saline, norepinephrine, and its α- and β-blockers were injected in the medial preoptic area and in some control areas of rats, during their sleeping and active periods. 5-Hydroxytryptamine was injected in the medial preoptic area in another group of animals. Simultaneous changes in sleep-wakefulness and the body temperature were continuously recorded. Norepinephrine produced hypothermia and arousal, whereas α-adrenergic blockers induced hyperthermia and sleep. These changes in body temperature and in sleep-wakefulness did not follow an identical time course. 5-Hydroxytryptamine induced hyperthermia without affecting sleep-wakefulness. It is suggested that there are different neuronal mechanisms in the medial preoptic area that bring about the drug-induced changes in temperature and sleep-wakefulness.",
author = "Subimal Datta and Kumar, {V. Mohan} and Chhina, {G. S.} and B. Singh",
year = "1988",
month = "1",
day = "1",
doi = "10.1016/0014-4886(88)90199-9",
language = "English (US)",
volume = "100",
pages = "40--50",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Interrelationship of thermal and sleep-wakefulness changes elicited from the medial preoptic area in rats

AU - Datta, Subimal

AU - Kumar, V. Mohan

AU - Chhina, G. S.

AU - Singh, B.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The study investigated the possible interrelationship between changes in sleep-wakefulness and body temperature, primarily induced by manipulation of the noradrenergic system in the medial preoptic area. Saline, norepinephrine, and its α- and β-blockers were injected in the medial preoptic area and in some control areas of rats, during their sleeping and active periods. 5-Hydroxytryptamine was injected in the medial preoptic area in another group of animals. Simultaneous changes in sleep-wakefulness and the body temperature were continuously recorded. Norepinephrine produced hypothermia and arousal, whereas α-adrenergic blockers induced hyperthermia and sleep. These changes in body temperature and in sleep-wakefulness did not follow an identical time course. 5-Hydroxytryptamine induced hyperthermia without affecting sleep-wakefulness. It is suggested that there are different neuronal mechanisms in the medial preoptic area that bring about the drug-induced changes in temperature and sleep-wakefulness.

AB - The study investigated the possible interrelationship between changes in sleep-wakefulness and body temperature, primarily induced by manipulation of the noradrenergic system in the medial preoptic area. Saline, norepinephrine, and its α- and β-blockers were injected in the medial preoptic area and in some control areas of rats, during their sleeping and active periods. 5-Hydroxytryptamine was injected in the medial preoptic area in another group of animals. Simultaneous changes in sleep-wakefulness and the body temperature were continuously recorded. Norepinephrine produced hypothermia and arousal, whereas α-adrenergic blockers induced hyperthermia and sleep. These changes in body temperature and in sleep-wakefulness did not follow an identical time course. 5-Hydroxytryptamine induced hyperthermia without affecting sleep-wakefulness. It is suggested that there are different neuronal mechanisms in the medial preoptic area that bring about the drug-induced changes in temperature and sleep-wakefulness.

UR - http://www.scopus.com/inward/record.url?scp=0023927868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023927868&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(88)90199-9

DO - 10.1016/0014-4886(88)90199-9

M3 - Article

C2 - 3350096

AN - SCOPUS:0023927868

VL - 100

SP - 40

EP - 50

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 1

ER -