Interrelationships among prostaglandins and vasoactive substances

A. Nasjletti, Kafait Malik

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Angiotensin II, norepinephrine, and kinins promote transformation of arachidonic acid to products that can in turn modify the actions of these vasoactive hormones on blood vessels and the kidney. Prostaglandins produced in response to angiotensin II or norepinephrine are instrumental in counteracting the vasoconstrictor actions of the vasoactive hormones. Prostaglandins produced in response to bradykinin amplify the vasodilatory action of the peptide, and mediate its action to increase urinary sodium excretion, and to reduce the reactivity of the renal vasculature to angiotensin II and norepinephrine. The interplay between prostaglandins and angiotensin II or norepinephrine is a dominant feature of processes regulating renal blood flow during activation of the renin-angiotensin or sympathetic nervous systems. The interplay among prostaglandins and kinins may be part of mechanisms promoting renal vasodilation and urinary sodium excretion.

Original languageEnglish (US)
Pages (from-to)881-889
Number of pages9
JournalMedical Clinics of North America
Volume65
Issue number4
DOIs
StatePublished - Jan 1 1981

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Angiotensin II
Prostaglandins
Norepinephrine
Kinins
Kidney
Sodium
Hormones
Renal Circulation
Sympathetic Nervous System
Angiotensins
Bradykinin
Vasoconstrictor Agents
Renin
Arachidonic Acid
Vasodilation
Blood Vessels
Peptides

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Interrelationships among prostaglandins and vasoactive substances. / Nasjletti, A.; Malik, Kafait.

In: Medical Clinics of North America, Vol. 65, No. 4, 01.01.1981, p. 881-889.

Research output: Contribution to journalArticle

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