Intima-media thickness and regional cérébral blood flow in older adults

Jitka Sojkova, Samer S. Najjar, Lori L. Beason-Held, E. Metter, Christos Davatzikos, Michael A. Kraut, Alan B. Zonderman, Susan M. Resnick

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background and Purpose-The relationship between the thickness of the carotid intima (IMT) and brain function remains unclear in those without clinical manifestations of cerebrovascular disease. Understanding the neural correlates of this vascular measure is important in view of emerging evidence linking poorer cognitive performance with increased IMT in individuals without clinical cerebrovascular disease. Methods-Seventy-three participants in the Baltimore Longitudinal Study of Aging (70.9 years; SD, 7.3) were evaluated with carotid artery ultrasound and resting [O]H2O positron emission tomography. Results-After adjusting for age, gender, and gray and white matter volumes in the regions where IMT is related to regional cérébral blood flow (rCBF), we found that higher IMT was associated with lower rCBF in lingual, inferior occipital, and superior temporal regions. Higher IMT was also associated with higher rCBF in medial frontal gyrus, putamen, and hippocampal-uncal regions (P=0.001). Whereas women had lower IMT (P=0.01) and mean arterial pressure (P=0.05) than men, they showed more robust associations between IMT and rCBF. The relationship between IMT and rCBF was only minimally affected by additional adjustment for mean arterial pressure. Conclusions-IMT is related to patterns of resting rCBF in older adults without clinical manifestations of cerebrovascular disease, suggesting that there are regional differences in CBF that are associated with subclinical vascular disease.

Original languageEnglish (US)
Pages (from-to)273-279
Number of pages7
JournalStroke
Volume41
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Regional Blood Flow
Cerebrovascular Disorders
Arterial Pressure
Baltimore
Putamen
Temporal Lobe
Prefrontal Cortex
Vascular Diseases
Carotid Arteries
Tongue
Positron-Emission Tomography
Blood Vessels
Longitudinal Studies
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Sojkova, J., Najjar, S. S., Beason-Held, L. L., Metter, E., Davatzikos, C., Kraut, M. A., ... Resnick, S. M. (2010). Intima-media thickness and regional cérébral blood flow in older adults. Stroke, 41(2), 273-279. https://doi.org/10.1161/STROKEAHA.109.566810

Intima-media thickness and regional cérébral blood flow in older adults. / Sojkova, Jitka; Najjar, Samer S.; Beason-Held, Lori L.; Metter, E.; Davatzikos, Christos; Kraut, Michael A.; Zonderman, Alan B.; Resnick, Susan M.

In: Stroke, Vol. 41, No. 2, 01.02.2010, p. 273-279.

Research output: Contribution to journalArticle

Sojkova, J, Najjar, SS, Beason-Held, LL, Metter, E, Davatzikos, C, Kraut, MA, Zonderman, AB & Resnick, SM 2010, 'Intima-media thickness and regional cérébral blood flow in older adults', Stroke, vol. 41, no. 2, pp. 273-279. https://doi.org/10.1161/STROKEAHA.109.566810
Sojkova J, Najjar SS, Beason-Held LL, Metter E, Davatzikos C, Kraut MA et al. Intima-media thickness and regional cérébral blood flow in older adults. Stroke. 2010 Feb 1;41(2):273-279. https://doi.org/10.1161/STROKEAHA.109.566810
Sojkova, Jitka ; Najjar, Samer S. ; Beason-Held, Lori L. ; Metter, E. ; Davatzikos, Christos ; Kraut, Michael A. ; Zonderman, Alan B. ; Resnick, Susan M. / Intima-media thickness and regional cérébral blood flow in older adults. In: Stroke. 2010 ; Vol. 41, No. 2. pp. 273-279.
@article{da25f997467842f5863592f4b1f9202e,
title = "Intima-media thickness and regional c{\'e}r{\'e}bral blood flow in older adults",
abstract = "Background and Purpose-The relationship between the thickness of the carotid intima (IMT) and brain function remains unclear in those without clinical manifestations of cerebrovascular disease. Understanding the neural correlates of this vascular measure is important in view of emerging evidence linking poorer cognitive performance with increased IMT in individuals without clinical cerebrovascular disease. Methods-Seventy-three participants in the Baltimore Longitudinal Study of Aging (70.9 years; SD, 7.3) were evaluated with carotid artery ultrasound and resting [O]H2O positron emission tomography. Results-After adjusting for age, gender, and gray and white matter volumes in the regions where IMT is related to regional c{\'e}r{\'e}bral blood flow (rCBF), we found that higher IMT was associated with lower rCBF in lingual, inferior occipital, and superior temporal regions. Higher IMT was also associated with higher rCBF in medial frontal gyrus, putamen, and hippocampal-uncal regions (P=0.001). Whereas women had lower IMT (P=0.01) and mean arterial pressure (P=0.05) than men, they showed more robust associations between IMT and rCBF. The relationship between IMT and rCBF was only minimally affected by additional adjustment for mean arterial pressure. Conclusions-IMT is related to patterns of resting rCBF in older adults without clinical manifestations of cerebrovascular disease, suggesting that there are regional differences in CBF that are associated with subclinical vascular disease.",
author = "Jitka Sojkova and Najjar, {Samer S.} and Beason-Held, {Lori L.} and E. Metter and Christos Davatzikos and Kraut, {Michael A.} and Zonderman, {Alan B.} and Resnick, {Susan M.}",
year = "2010",
month = "2",
day = "1",
doi = "10.1161/STROKEAHA.109.566810",
language = "English (US)",
volume = "41",
pages = "273--279",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Intima-media thickness and regional cérébral blood flow in older adults

AU - Sojkova, Jitka

AU - Najjar, Samer S.

AU - Beason-Held, Lori L.

AU - Metter, E.

AU - Davatzikos, Christos

AU - Kraut, Michael A.

AU - Zonderman, Alan B.

AU - Resnick, Susan M.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Background and Purpose-The relationship between the thickness of the carotid intima (IMT) and brain function remains unclear in those without clinical manifestations of cerebrovascular disease. Understanding the neural correlates of this vascular measure is important in view of emerging evidence linking poorer cognitive performance with increased IMT in individuals without clinical cerebrovascular disease. Methods-Seventy-three participants in the Baltimore Longitudinal Study of Aging (70.9 years; SD, 7.3) were evaluated with carotid artery ultrasound and resting [O]H2O positron emission tomography. Results-After adjusting for age, gender, and gray and white matter volumes in the regions where IMT is related to regional cérébral blood flow (rCBF), we found that higher IMT was associated with lower rCBF in lingual, inferior occipital, and superior temporal regions. Higher IMT was also associated with higher rCBF in medial frontal gyrus, putamen, and hippocampal-uncal regions (P=0.001). Whereas women had lower IMT (P=0.01) and mean arterial pressure (P=0.05) than men, they showed more robust associations between IMT and rCBF. The relationship between IMT and rCBF was only minimally affected by additional adjustment for mean arterial pressure. Conclusions-IMT is related to patterns of resting rCBF in older adults without clinical manifestations of cerebrovascular disease, suggesting that there are regional differences in CBF that are associated with subclinical vascular disease.

AB - Background and Purpose-The relationship between the thickness of the carotid intima (IMT) and brain function remains unclear in those without clinical manifestations of cerebrovascular disease. Understanding the neural correlates of this vascular measure is important in view of emerging evidence linking poorer cognitive performance with increased IMT in individuals without clinical cerebrovascular disease. Methods-Seventy-three participants in the Baltimore Longitudinal Study of Aging (70.9 years; SD, 7.3) were evaluated with carotid artery ultrasound and resting [O]H2O positron emission tomography. Results-After adjusting for age, gender, and gray and white matter volumes in the regions where IMT is related to regional cérébral blood flow (rCBF), we found that higher IMT was associated with lower rCBF in lingual, inferior occipital, and superior temporal regions. Higher IMT was also associated with higher rCBF in medial frontal gyrus, putamen, and hippocampal-uncal regions (P=0.001). Whereas women had lower IMT (P=0.01) and mean arterial pressure (P=0.05) than men, they showed more robust associations between IMT and rCBF. The relationship between IMT and rCBF was only minimally affected by additional adjustment for mean arterial pressure. Conclusions-IMT is related to patterns of resting rCBF in older adults without clinical manifestations of cerebrovascular disease, suggesting that there are regional differences in CBF that are associated with subclinical vascular disease.

UR - http://www.scopus.com/inward/record.url?scp=77449153561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77449153561&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.109.566810

DO - 10.1161/STROKEAHA.109.566810

M3 - Article

VL - 41

SP - 273

EP - 279

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 2

ER -