Intolerance to protein hydrolysate infant formulas

An underrecognized cause of gastrointestinal symptoms in infants

J. A. Vanderhoof, N. D. Murray, S. S. Kaufman, D. Mack, D. L. Antonson, Mark Corkins, D. Perry, R. Kruger

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

The purpose of this study was to determine the effectiveness of an amino acid-based infant formula in infants with continued symptoms suggestive of formula protein intolerance while they were receiving casein hydrolysate formula (CHF). Twenty-eight infants, 22 to 173 days of age, were enrolled; each had received CHF for an average of 40 days (10 to 173 days) and continued to have bloody stools, vomiting, diarrhea, irritability, or failure to gain weight, or a combination of these symptoms. Sigmoidoscopy with rectal biopsy was performed in all infants. The infants then received an amino acid- based infant formula, Neocate, for 2 weeks. After 2 weeks of treatment, 25 of the infants demonstrated resolution of their symptoms and underwent challenge with CHF. Of the 25 who were challenged, eight tolerated the CHF and the remainder had recurrence of their symptoms. The histologic features in these infants varied from eosinophilic infiltration to normal. We conclude that not all infants with apparent formula protein-induced colitis respond to CHF and that these infants may have resolution of their symptoms when fed an amino acid-based infant formula.

Original languageEnglish (US)
Pages (from-to)741-744
Number of pages4
JournalJournal of Pediatrics
Volume131
Issue number5
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Protein Hydrolysates
Infant Formula
Amino Acids
Sigmoidoscopy
Colitis
Weight Gain
Vomiting
Diarrhea
Proteins
casein hydrolysate
Biopsy
Recurrence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Intolerance to protein hydrolysate infant formulas : An underrecognized cause of gastrointestinal symptoms in infants. / Vanderhoof, J. A.; Murray, N. D.; Kaufman, S. S.; Mack, D.; Antonson, D. L.; Corkins, Mark; Perry, D.; Kruger, R.

In: Journal of Pediatrics, Vol. 131, No. 5, 01.01.1997, p. 741-744.

Research output: Contribution to journalArticle

Vanderhoof, J. A. ; Murray, N. D. ; Kaufman, S. S. ; Mack, D. ; Antonson, D. L. ; Corkins, Mark ; Perry, D. ; Kruger, R. / Intolerance to protein hydrolysate infant formulas : An underrecognized cause of gastrointestinal symptoms in infants. In: Journal of Pediatrics. 1997 ; Vol. 131, No. 5. pp. 741-744.
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