Intracardiac renin-angiotensin system and myocardial repair/remodeling following infarction

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

The circulating renin-angiotensin system (RAS) is a classic endocrine system that regulates cardiovascular homeostasis during physiologic and pathologic states. Accumulated evidence has shown the presence of components of RAS in various tissues, which are upregulated in certain pathological conditions. Locally produced angiotensin (Ang)II may play an important role in tissue repair/remodeling in autocrine and/or paracrine manners. Following acute myocardial infarction (MI), cardiac repair occurs in the infarcted myocardium and structural remodeling is developed in noninfarcted myocardium, which are accompanied by activated cardiac RAS. In this review, the current understanding of independent activation of cardiac RAS and its regulation in the pathogenesis of myocardial repair/remodeling after MI is discussed.

Original languageEnglish (US)
Pages (from-to)483-489
Number of pages7
JournalJournal of Molecular and Cellular Cardiology
Volume48
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Renin-Angiotensin System
Infarction
Myocardium
Myocardial Infarction
Endocrine System
Angiotensin II
Homeostasis

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Intracardiac renin-angiotensin system and myocardial repair/remodeling following infarction. / Sun, Yao.

In: Journal of Molecular and Cellular Cardiology, Vol. 48, No. 3, 01.03.2010, p. 483-489.

Research output: Contribution to journalReview article

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