Intracellular levels and extracellular release of lysosomal enzymes from peripheral blood monocytes in pulmonary tuberculosis patients

S. JASWAL, Rajiv Dhand, A. K. SETHI, K. K. KOHLI, N. K. GANGULY

Research output: Contribution to journalArticle

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Abstract

The intracellular activity and extracellular release (basal and latex‐stimulated) of B‐glucuronidase (BG) and N‐acetylglucosaminidase (NAG), measured fluorimetrically, were observed to be significantly (P<0.05) higher in blood monocytes (BM) of untreated pulmonary tuberculosis (TB) patients compared to those of age‐ and sex‐matched controls and Mantoux‐positive subjects without any evidence of active disease. After completion of antituberculous therapy, BG and NAG activities declined appreciably (P<0.05) and their levels became comparable to those in control subjects. The present results suggest the potentiation of the oxygen‐independent defense mechanism of BM in pulmonary TB.

Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalAPMIS
Volume101
Issue number1-6
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Pulmonary Tuberculosis
Monocytes
Enzymes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Intracellular levels and extracellular release of lysosomal enzymes from peripheral blood monocytes in pulmonary tuberculosis patients. / JASWAL, S.; Dhand, Rajiv; SETHI, A. K.; KOHLI, K. K.; GANGULY, N. K.

In: APMIS, Vol. 101, No. 1-6, 01.01.1993, p. 50-54.

Research output: Contribution to journalArticle

JASWAL, S. ; Dhand, Rajiv ; SETHI, A. K. ; KOHLI, K. K. ; GANGULY, N. K. / Intracellular levels and extracellular release of lysosomal enzymes from peripheral blood monocytes in pulmonary tuberculosis patients. In: APMIS. 1993 ; Vol. 101, No. 1-6. pp. 50-54.
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