Intracranial pressure monitoring

Relationship between indices of cerebrovascular reserve, system bandwidth, and cerebral perfusion

M. L. Daley, Sulhyung Han, Shelly D. Timmons, Massroor Pourcyrous, Charles Leffler

Research output: Contribution to journalConference article

Abstract

Loss of cerebrovascular reserve with the resultant increase of cerebral perfusion, and disruption of capillary fluid balance generally leads to the development of cerebral edema, a serious secondary complication of traumatic brain injury. Two indices of cerebrovascular reserved derived from recordings of intracranial pressure (ICP) and arterial blood pressure (ABP) have been proposed [1-3]. The purpose of this study was to examine the relationship between changes of arteriolar resistance, cerebral perfusion, system bandwidth, and the indices of cerebrovascular reserve during dilatory challenge induced by ventilation with CO 2 . Steady state values of arteriolar diameter significantly increased during hypercapnia resulting in a decrease of arteriolar resistance by more than 90%. Cerebral perfusion pressure (CPP) was found to range from -18% to 12%. Significant correlation between percent change of relative flow and either indices of cerebrovascular reserve, arteriolar resistance, or system bandwidth were not determined. System bandwidth between ABP and ICP and the Correlation Index of cerebrovascular reserve (CorrX), were found to be exponentially correlated with values ranging from 0.85 to .99 with a group (n=5) mean (+S.D.) of 0.94 (+0.06). Such a relationship suggests that near minimal tone, further losses of tone lead to changes of stiffness that produce large changes in system bandwidth.

Original languageEnglish (US)
Pages (from-to)263-265
Number of pages3
JournalAnnual Reports of the Research Reactor Institute, Kyoto University
Volume1
StatePublished - Dec 1 2001
Externally publishedYes
Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Istanbul, Turkey
Duration: Oct 25 2001Oct 28 2001

Fingerprint

Bandwidth
Monitoring
Blood pressure
Ventilation
Brain
Stiffness
Fluids

All Science Journal Classification (ASJC) codes

  • Energy Engineering and Power Technology
  • Mechanical Engineering

Cite this

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title = "Intracranial pressure monitoring: Relationship between indices of cerebrovascular reserve, system bandwidth, and cerebral perfusion",
abstract = "Loss of cerebrovascular reserve with the resultant increase of cerebral perfusion, and disruption of capillary fluid balance generally leads to the development of cerebral edema, a serious secondary complication of traumatic brain injury. Two indices of cerebrovascular reserved derived from recordings of intracranial pressure (ICP) and arterial blood pressure (ABP) have been proposed [1-3]. The purpose of this study was to examine the relationship between changes of arteriolar resistance, cerebral perfusion, system bandwidth, and the indices of cerebrovascular reserve during dilatory challenge induced by ventilation with CO 2 . Steady state values of arteriolar diameter significantly increased during hypercapnia resulting in a decrease of arteriolar resistance by more than 90{\%}. Cerebral perfusion pressure (CPP) was found to range from -18{\%} to 12{\%}. Significant correlation between percent change of relative flow and either indices of cerebrovascular reserve, arteriolar resistance, or system bandwidth were not determined. System bandwidth between ABP and ICP and the Correlation Index of cerebrovascular reserve (CorrX), were found to be exponentially correlated with values ranging from 0.85 to .99 with a group (n=5) mean (+S.D.) of 0.94 (+0.06). Such a relationship suggests that near minimal tone, further losses of tone lead to changes of stiffness that produce large changes in system bandwidth.",
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T2 - Relationship between indices of cerebrovascular reserve, system bandwidth, and cerebral perfusion

AU - Daley, M. L.

AU - Han, Sulhyung

AU - Timmons, Shelly D.

AU - Pourcyrous, Massroor

AU - Leffler, Charles

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Loss of cerebrovascular reserve with the resultant increase of cerebral perfusion, and disruption of capillary fluid balance generally leads to the development of cerebral edema, a serious secondary complication of traumatic brain injury. Two indices of cerebrovascular reserved derived from recordings of intracranial pressure (ICP) and arterial blood pressure (ABP) have been proposed [1-3]. The purpose of this study was to examine the relationship between changes of arteriolar resistance, cerebral perfusion, system bandwidth, and the indices of cerebrovascular reserve during dilatory challenge induced by ventilation with CO 2 . Steady state values of arteriolar diameter significantly increased during hypercapnia resulting in a decrease of arteriolar resistance by more than 90%. Cerebral perfusion pressure (CPP) was found to range from -18% to 12%. Significant correlation between percent change of relative flow and either indices of cerebrovascular reserve, arteriolar resistance, or system bandwidth were not determined. System bandwidth between ABP and ICP and the Correlation Index of cerebrovascular reserve (CorrX), were found to be exponentially correlated with values ranging from 0.85 to .99 with a group (n=5) mean (+S.D.) of 0.94 (+0.06). Such a relationship suggests that near minimal tone, further losses of tone lead to changes of stiffness that produce large changes in system bandwidth.

AB - Loss of cerebrovascular reserve with the resultant increase of cerebral perfusion, and disruption of capillary fluid balance generally leads to the development of cerebral edema, a serious secondary complication of traumatic brain injury. Two indices of cerebrovascular reserved derived from recordings of intracranial pressure (ICP) and arterial blood pressure (ABP) have been proposed [1-3]. The purpose of this study was to examine the relationship between changes of arteriolar resistance, cerebral perfusion, system bandwidth, and the indices of cerebrovascular reserve during dilatory challenge induced by ventilation with CO 2 . Steady state values of arteriolar diameter significantly increased during hypercapnia resulting in a decrease of arteriolar resistance by more than 90%. Cerebral perfusion pressure (CPP) was found to range from -18% to 12%. Significant correlation between percent change of relative flow and either indices of cerebrovascular reserve, arteriolar resistance, or system bandwidth were not determined. System bandwidth between ABP and ICP and the Correlation Index of cerebrovascular reserve (CorrX), were found to be exponentially correlated with values ranging from 0.85 to .99 with a group (n=5) mean (+S.D.) of 0.94 (+0.06). Such a relationship suggests that near minimal tone, further losses of tone lead to changes of stiffness that produce large changes in system bandwidth.

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