Intractable epilepsy due to meningitis

Results of surgery and pathological findings

K. G. Davies, B. P. Hermann, F Dohan, A. R. Wyler

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Between 1986 and 1992, among a total of 668 craniotomies performed for intractable epilepsy, 13 (1.9%) patients had a presumed aetiology of a previous episode of meningitis. Twelve were investigated with chronic electrocorticography with subdural electrodes which showed mesial temporal onset in eight, regional temporal onset in three and bilateral diffuse onset in one. One patient underwent corpus callosotomy and 12 anterior temporal lobectomy (ATL) (6L, 6R). The pathology in the resection cases was hippocampal sclerosis in six and gliosis in six. Mean length of follow up was 3 years (range 1-6 years). Ten of the 12 (83%) ATL patients were seizure free (six off medications). Two ATL patients and the callosotomy patient were significantly improved. It is concluded that in patients where the presumed aetiology of intractable epilepsy is meningitis and widespread damage may therefore be expected, this does not necessarily indicate multifocality, and the prognosis following resective surgery appears to be good.

Original languageEnglish (US)
Pages (from-to)567-570
Number of pages4
JournalBritish Journal of Neurosurgery
Volume10
Issue number6
DOIs
StatePublished - Dec 1 1996

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Meningitis
Anterior Temporal Lobectomy
Gliosis
Craniotomy
Sclerosis
Drug Resistant Epilepsy
Electrodes
Seizures
Pathology

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Intractable epilepsy due to meningitis : Results of surgery and pathological findings. / Davies, K. G.; Hermann, B. P.; Dohan, F; Wyler, A. R.

In: British Journal of Neurosurgery, Vol. 10, No. 6, 01.12.1996, p. 567-570.

Research output: Contribution to journalArticle

Davies, K. G. ; Hermann, B. P. ; Dohan, F ; Wyler, A. R. / Intractable epilepsy due to meningitis : Results of surgery and pathological findings. In: British Journal of Neurosurgery. 1996 ; Vol. 10, No. 6. pp. 567-570.
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