Intradermal Botulinum Toxin Type A Injection Effectively Reduces Residual Limb Hyperhidrosis in Amputees: A Case Series

Alexandra Charrow, Marc DiFazio, Leslie Foster, Paul F. Pasquina, Jack Tsao

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Charrow A, DiFazio M, Foster L, Pasquina PF, Tsao JW. Intradermal botulinum toxin type A injection effectively reduces residual limb hyperhidrosis in amputees: a case series. Objective: To study the effectiveness of botulinum toxin type A (BTX-A) therapy for residual limb hyperhidrosis, prosthesis fit and function, and residual and phantom limb pain in patients with limb amputation. Design: Consecutive case series. Setting: Outpatient physical medicine and rehabilitation clinic. Participants: Walter Reed Army Medical Center patients (N=8) with unilateral traumatic upper- or lower-limb amputation. Intervention: BTX-A was injected transdermally in a circumferential pattern around the residual limb by using a 1-cm matrix grid. Main Outcome Measure: A 10-cm continuous Likert visual analog scale was used to assess residual limb sweating and pain and prosthesis fit and function before and 3 weeks after BTX-A injections. Results: Patients reported a significant reduction in sweating and improvement in prosthesis fit and function after treatment. However, residual limb and phantom pain were unaffected by treatment. Conclusions: BTX-A may be an effective treatment for residual limb hyperhidrosis, resulting in subjective improvement in prosthesis fit and functioning. BTX-A should be considered as a method to manage excessive sweating in the residual limb of traumatic amputees.

Original languageEnglish (US)
Pages (from-to)1407-1409
Number of pages3
JournalArchives of Physical Medicine and Rehabilitation
Volume89
Issue number7
DOIs
StatePublished - Jul 1 2008

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Hyperhidrosis
Amputees
Type A Botulinum Toxins
Extremities
Injections
Sweating
Phantom Limb
Prostheses and Implants
Amputation
Artificial Limbs
Physical and Rehabilitation Medicine
antineoplaston A10
Therapeutics
Visual Analog Scale
Lower Extremity
Outpatients
Outcome Assessment (Health Care)
Pain

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

Cite this

Intradermal Botulinum Toxin Type A Injection Effectively Reduces Residual Limb Hyperhidrosis in Amputees : A Case Series. / Charrow, Alexandra; DiFazio, Marc; Foster, Leslie; Pasquina, Paul F.; Tsao, Jack.

In: Archives of Physical Medicine and Rehabilitation, Vol. 89, No. 7, 01.07.2008, p. 1407-1409.

Research output: Contribution to journalArticle

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