Intraocular Pressure-denpendent Retinal Vascular Change in Adult Chronic Open-angle Glaucoma Patients

Dong H. Shin, Clark S. Tsai, Kyle A. Parrow, Chaesik Kim, Jim Wan, Dian X. Shi

Research output: Contribution to journalArticle

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Abstract

Intraocular pressure (IOP)-dependent retinal vascular changes were investigated in 33 eyes of 33 adult chronic open-angle glaucoma (COAG) patients by measuring major retinal vascular calibers at the optic disc border before and after mean (± standard deviation) IOP reduction from 35.3 (±7.2) to 16.5 (±4.7) mmHg for 11.2 (±13.5) weeks. Both mean arterial and venous calibers were significantly reduced (P < 0.0001 for each), from 87.8 (±14.2) and 128.3 (±20.8) Am at high IOP to 82.0 (±13.8) and 121.4 (±18.5) µm at low IOP. Arterial and venous caliber decreases correlated positively with magnitude of IOP reduction (P = 0.503, P < 0.01 and r = 0.555, P < 0.001, respectively). While the IOP-dependent retinal arterial caliber change was highly significant in patients 55 years of age or younger (P = 0.636, P < 0.01) and in the overall study group, it was not significant in patients older than 55 years (P = 0.205, P > 0.1). Age seems to be more influential than magnitude of IOP reduction in patients older than 55. Thus, diminished IOP-dependent retinal arterial caliber change in the elderly may be one factor contributing to the higher incidence and prevalence of glaucoma in this population.

Original languageEnglish (US)
Pages (from-to)1087-1092
Number of pages6
JournalOphthalmology
Volume98
Issue number7
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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Retinal Vessels
Open Angle Glaucoma
Intraocular Pressure
Optic Disk
Glaucoma
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Intraocular Pressure-denpendent Retinal Vascular Change in Adult Chronic Open-angle Glaucoma Patients. / Shin, Dong H.; Tsai, Clark S.; Parrow, Kyle A.; Kim, Chaesik; Wan, Jim; Shi, Dian X.

In: Ophthalmology, Vol. 98, No. 7, 01.01.1991, p. 1087-1092.

Research output: Contribution to journalArticle

Shin, Dong H. ; Tsai, Clark S. ; Parrow, Kyle A. ; Kim, Chaesik ; Wan, Jim ; Shi, Dian X. / Intraocular Pressure-denpendent Retinal Vascular Change in Adult Chronic Open-angle Glaucoma Patients. In: Ophthalmology. 1991 ; Vol. 98, No. 7. pp. 1087-1092.
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