Intraoperative imprint cytology for sentinel lymph node evaluation of merkel cell carcinoma

A case report

Yorke Young, Amy C. Parsons, Edward A. Levine, Kim R. Geisinger

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Merkel cell carcinoma is a rare skin cancer, which is more aggressive and more lethal than melanoma. Merkel cell carcinoma tends to spread to regional lymph nodes and, consequently, lymph node status is the strongest predictor of survival. Of all the staging alternatives, intraoperative sentinel lymph node (SLN) biopsy seems to be the best option by quickly affording clinicians the advantage of averting unnecessary surgery in patients with negative SLNs, while providing the option of continuing on to therapeutic lymph node dissection for patients detected with node-positive disease. For evaluation of SLN biopsies, intraoperative imprint cytology (IIC) demonstrates equivalent sensitivity, specificity, and diagnostic accuracy as frozen sections while offering greater preservation of nuclear and cytoplasmic detail without freezing artifact, retention of all tissue for permanent sections, quicker and less labor intensive preparation, and lower costs. For these reasons, IIC should be the preferred method of examination for SLN biopsies for patients with Merkel cell carcinoma. We report a case of metastatic Merkel cell carcinoma diagnosed by evaluation of SLNs using IIC.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalPathology Case Reviews
Volume13
Issue number3
DOIs
StatePublished - May 1 2008
Externally publishedYes

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Merkel Cell Carcinoma
Sentinel Lymph Node Biopsy
Cell Biology
Lymph Nodes
Unnecessary Procedures
Frozen Sections
Skin Neoplasms
Lymph Node Excision
Artifacts
Freezing
Melanoma
Costs and Cost Analysis
Sensitivity and Specificity
Survival
Sentinel Lymph Node

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Intraoperative imprint cytology for sentinel lymph node evaluation of merkel cell carcinoma : A case report. / Young, Yorke; Parsons, Amy C.; Levine, Edward A.; Geisinger, Kim R.

In: Pathology Case Reviews, Vol. 13, No. 3, 01.05.2008, p. 109-113.

Research output: Contribution to journalArticle

Young, Yorke ; Parsons, Amy C. ; Levine, Edward A. ; Geisinger, Kim R. / Intraoperative imprint cytology for sentinel lymph node evaluation of merkel cell carcinoma : A case report. In: Pathology Case Reviews. 2008 ; Vol. 13, No. 3. pp. 109-113.
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