Intrarenal schwannoma

A report of four cases including three cellular variants

Isabel Alvarado-Cabrero, Andrew L. Folpe, John R. Srigley, Paul Gaudin, Abraham T. Philip, Victor E. Reuter, Mahul Amin

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Renal schwannomas are extraordinarily rare neoplasms; only six have been reported, the majority of which occurred in the renal pelvis. We report the clinical and pathologic features of four additional cases. The resected kidney in all patients contained a well-demarcated, yellow-tan, smooth, and bulging intraparenchymal tumor (mean size, 9.7 cm; range, 4 to 16 cm). Microscopically, three cases were classified as cellular schwannomas, and one was a usual-type schwannoma, with degenerative nuclear atypia. By immunohistochemistry, all tumors were strongly S-100 protein positive and negative for pan-cytokeratin, CD57, smooth muscle actin, desmin, and CD34. Epithelial elements were not noted in the tumors, and there was no history of any clinical syndromes in these patients. Analysis of the four cases showed the mean age at presentation to be 47 years (range, 18 to 84 years), with no sex predisposition (two men, two women). Most patients were asymptomatic, and all received a diagnosis of renal cell carcinoma and treated as having such. Recognition and awareness of these rare, benign tumors will assist in the differential diagnosis of spindle cell tumors of the kidney and prevent their misdiagnosis as sarcomatoid carcinomas of the kidney or renal sarcomas. Our study, the largest series to date of renal schwannomas, demonstrates a predilection for the cellular variant in the kidney, documents that these tumors may present in the nonhilar region of the kidney, and provides clinical evidence of their benign biologic behavior.

Original languageEnglish (US)
Pages (from-to)851-856
Number of pages6
JournalModern Pathology
Volume13
Issue number8
DOIs
StatePublished - Jan 1 2000

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Neurilemmoma
Kidney
Neoplasms
Kidney Pelvis
Desmin
S100 Proteins
Keratins
Diagnostic Errors
Renal Cell Carcinoma
Sarcoma
Smooth Muscle
Actins
Differential Diagnosis
Immunohistochemistry
Carcinoma

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Alvarado-Cabrero, I., Folpe, A. L., Srigley, J. R., Gaudin, P., Philip, A. T., Reuter, V. E., & Amin, M. (2000). Intrarenal schwannoma: A report of four cases including three cellular variants. Modern Pathology, 13(8), 851-856. https://doi.org/10.1038/modpathol.3880150

Intrarenal schwannoma : A report of four cases including three cellular variants. / Alvarado-Cabrero, Isabel; Folpe, Andrew L.; Srigley, John R.; Gaudin, Paul; Philip, Abraham T.; Reuter, Victor E.; Amin, Mahul.

In: Modern Pathology, Vol. 13, No. 8, 01.01.2000, p. 851-856.

Research output: Contribution to journalArticle

Alvarado-Cabrero, I, Folpe, AL, Srigley, JR, Gaudin, P, Philip, AT, Reuter, VE & Amin, M 2000, 'Intrarenal schwannoma: A report of four cases including three cellular variants', Modern Pathology, vol. 13, no. 8, pp. 851-856. https://doi.org/10.1038/modpathol.3880150
Alvarado-Cabrero I, Folpe AL, Srigley JR, Gaudin P, Philip AT, Reuter VE et al. Intrarenal schwannoma: A report of four cases including three cellular variants. Modern Pathology. 2000 Jan 1;13(8):851-856. https://doi.org/10.1038/modpathol.3880150
Alvarado-Cabrero, Isabel ; Folpe, Andrew L. ; Srigley, John R. ; Gaudin, Paul ; Philip, Abraham T. ; Reuter, Victor E. ; Amin, Mahul. / Intrarenal schwannoma : A report of four cases including three cellular variants. In: Modern Pathology. 2000 ; Vol. 13, No. 8. pp. 851-856.
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