Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients

Mariana de Pauli Paglioni, Wagner Gomes Silva, Juliana Pereira, Cesar Migliorati, Marcio Ajudarte Lopes, Oslei Paes de Almeida, Mario Fernando Goes, Ana Carolina Prado Ribeiro, Thais Bianca Brandão, Alan Roger Santos-Silva

Research output: Contribution to journalArticle

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Abstract

Objective To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients. Study Design Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy. PDL was assessed by optical light microscopy and the immunohistochemical expression of periostin. Results No significant difference was detected in cementum thickness (apical, P = .06; medium, P = .16; cervical, P = .18) between groups. The numbers of fibroblasts in PDL (P = .56), incremental lines of cementum (P = .51) and the immunohistochemical patterns of periostin expression in PDL (P = .68) did not differ between groups. Conclusion IV BP therapy does not thicken cementum or change the micromorphology of PDL.

Original languageEnglish (US)
Pages (from-to)591-599
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume123
Issue number5
DOIs
StatePublished - May 1 2017

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Dental Cementum
Periodontal Ligament
Diphosphonates
Neoplasms
Polarization Microscopy
Tooth Root
Therapeutics
Microscopy
Tooth
Fibroblasts
Light

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

Cite this

de Pauli Paglioni, M., Gomes Silva, W., Pereira, J., Migliorati, C., Lopes, M. A., de Almeida, O. P., ... Santos-Silva, A. R. (2017). Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 123(5), 591-599. https://doi.org/10.1016/j.oooo.2017.02.008

Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients. / de Pauli Paglioni, Mariana; Gomes Silva, Wagner; Pereira, Juliana; Migliorati, Cesar; Lopes, Marcio Ajudarte; de Almeida, Oslei Paes; Goes, Mario Fernando; Ribeiro, Ana Carolina Prado; Brandão, Thais Bianca; Santos-Silva, Alan Roger.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 123, No. 5, 01.05.2017, p. 591-599.

Research output: Contribution to journalArticle

de Pauli Paglioni, M, Gomes Silva, W, Pereira, J, Migliorati, C, Lopes, MA, de Almeida, OP, Goes, MF, Ribeiro, ACP, Brandão, TB & Santos-Silva, AR 2017, 'Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 123, no. 5, pp. 591-599. https://doi.org/10.1016/j.oooo.2017.02.008
de Pauli Paglioni, Mariana ; Gomes Silva, Wagner ; Pereira, Juliana ; Migliorati, Cesar ; Lopes, Marcio Ajudarte ; de Almeida, Oslei Paes ; Goes, Mario Fernando ; Ribeiro, Ana Carolina Prado ; Brandão, Thais Bianca ; Santos-Silva, Alan Roger. / Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2017 ; Vol. 123, No. 5. pp. 591-599.
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abstract = "Objective To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients. Study Design Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy. PDL was assessed by optical light microscopy and the immunohistochemical expression of periostin. Results No significant difference was detected in cementum thickness (apical, P = .06; medium, P = .16; cervical, P = .18) between groups. The numbers of fibroblasts in PDL (P = .56), incremental lines of cementum (P = .51) and the immunohistochemical patterns of periostin expression in PDL (P = .68) did not differ between groups. Conclusion IV BP therapy does not thicken cementum or change the micromorphology of PDL.",
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AU - Gomes Silva, Wagner

AU - Pereira, Juliana

AU - Migliorati, Cesar

AU - Lopes, Marcio Ajudarte

AU - de Almeida, Oslei Paes

AU - Goes, Mario Fernando

AU - Ribeiro, Ana Carolina Prado

AU - Brandão, Thais Bianca

AU - Santos-Silva, Alan Roger

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N2 - Objective To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients. Study Design Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy. PDL was assessed by optical light microscopy and the immunohistochemical expression of periostin. Results No significant difference was detected in cementum thickness (apical, P = .06; medium, P = .16; cervical, P = .18) between groups. The numbers of fibroblasts in PDL (P = .56), incremental lines of cementum (P = .51) and the immunohistochemical patterns of periostin expression in PDL (P = .68) did not differ between groups. Conclusion IV BP therapy does not thicken cementum or change the micromorphology of PDL.

AB - Objective To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients. Study Design Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy. PDL was assessed by optical light microscopy and the immunohistochemical expression of periostin. Results No significant difference was detected in cementum thickness (apical, P = .06; medium, P = .16; cervical, P = .18) between groups. The numbers of fibroblasts in PDL (P = .56), incremental lines of cementum (P = .51) and the immunohistochemical patterns of periostin expression in PDL (P = .68) did not differ between groups. Conclusion IV BP therapy does not thicken cementum or change the micromorphology of PDL.

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