Intraventricular haemorrhage in preterm infants

Evidence of suppressed fibrinolysis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Intraventricular hemorrhage (IVH) in premature infants may be related to the immaturity of the vascular bed in the germinal matrix. We measured six hemostatic parameters whose alterations may represent an additional risk factor for IVH in preterm infants. On postnatal day 1 there were differences between plasminogen activator inhibitor-1 (PAI-1) activity and antigen, of both full-term and preterm infants with and without IVH (P<0.05). Preterms with IVH were different to both full-terms and preterms without IVH. No difference was observed in plasma concentrations of fibrinogen, plasminogen and von Willebrand factor. Plasma concentrations of antithrombin m were significantly higher in full-term infants than in preterm infants. The difference between the platelet counts of preterm infants with and without IVH was not significant (P>0.05). Elevation of crosslinked fibrin degradation products (XDP), determined by the SimpliRED(TM) D-dimer test, correlated in four out of five premature infants with the diagnosis of IVH by ultrasonography. No elevation of D-dimer XDP was observed in premature infants without IVH (11/12) and full-term infants (6/6). In conclusion, a hypercoagulable state, indicated by a rise in D-dimer XDP, may be initiated by some types of trauma to fragile blood vessels of the preterm infants who develop ITH. This hypercoagulability is further exacerbated by the increased release of PAI-1 leading to suppressed fibrinolysis.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalBlood Coagulation and Fibrinolysis
Volume7
Issue number3
DOIs
StatePublished - Jan 1 1996

Fingerprint

Fibrinolysis
Premature Infants
Hemorrhage
Plasminogen Activator Inhibitor 1
Blood Vessels
Fibrin Fibrinogen Degradation Products
Thrombophilia
Hemostatics
Ultrasonography
Antigens
Wounds and Injuries
fibrin fragment D

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Intraventricular haemorrhage in preterm infants : Evidence of suppressed fibrinolysis. / Chen, James; Lorch, Vichien.

In: Blood Coagulation and Fibrinolysis, Vol. 7, No. 3, 01.01.1996, p. 289-294.

Research output: Contribution to journalArticle

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