Introducing nanochemoprevention as a novel approach for cancer control

Proof of principle with green tea polyphenol epigallocatechin-3-gallate

Imtiaz A. Siddiqui, Vaqar M. Adhami, Dhruba J. Bharali, Bilal Hafeez, Mohammad Asim, Sabih I. Khwaja, Nihal Ahmad, Huadong Cui, Shaker A. Mousa, Hasan Mukhtar

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

Chemoprevention, especially through the use of naturally occurring phytochemicals capable of impeding the process of one or more steps of carcinogenesis process, is a promising approach for cancer management. Despite promising results in preclinical settings, its applicability to humans has met with limited success largely due to inefficient systemic delivery and bioavailability of promising chemopreventive agents. Here, we introduce the concept of nanochemoprevention, which uses nanotechnology for enhancing the outcome of chemoprevention. We encapsulated green tea polyphenol epigallocatechin-3-gallate (EGCG) in polylactic acid-polyethylene glycol nanoparticles and observed that encapsulated EGCG retains its biological effectiveness with over 10-fold dose advantage for exerting its proapoptotic and angiogenesis inhibitory effects, critically important determinants of chemopreventive effects of EGCG in both in vitro and in vivo systems. Thus, this study could serve as a basis for the use of nanoparticle-mediated delivery to enhance bioavailability and limit any unwanted toxicity of chemopreventive agents, Such as EGCG.

Original languageEnglish (US)
Pages (from-to)1712-1716
Number of pages5
JournalCancer Research
Volume69
Issue number5
DOIs
StatePublished - Mar 1 2009
Externally publishedYes

Fingerprint

Polyphenols
Tea
Chemoprevention
Nanoparticles
Biological Availability
Neoplasms
Nanotechnology
Angiogenesis Inducing Agents
Phytochemicals
Carcinogenesis
epigallocatechin gallate

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Introducing nanochemoprevention as a novel approach for cancer control : Proof of principle with green tea polyphenol epigallocatechin-3-gallate. / Siddiqui, Imtiaz A.; Adhami, Vaqar M.; Bharali, Dhruba J.; Hafeez, Bilal; Asim, Mohammad; Khwaja, Sabih I.; Ahmad, Nihal; Cui, Huadong; Mousa, Shaker A.; Mukhtar, Hasan.

In: Cancer Research, Vol. 69, No. 5, 01.03.2009, p. 1712-1716.

Research output: Contribution to journalArticle

Siddiqui, IA, Adhami, VM, Bharali, DJ, Hafeez, B, Asim, M, Khwaja, SI, Ahmad, N, Cui, H, Mousa, SA & Mukhtar, H 2009, 'Introducing nanochemoprevention as a novel approach for cancer control: Proof of principle with green tea polyphenol epigallocatechin-3-gallate', Cancer Research, vol. 69, no. 5, pp. 1712-1716. https://doi.org/10.1158/0008-5472.CAN-08-3978
Siddiqui, Imtiaz A. ; Adhami, Vaqar M. ; Bharali, Dhruba J. ; Hafeez, Bilal ; Asim, Mohammad ; Khwaja, Sabih I. ; Ahmad, Nihal ; Cui, Huadong ; Mousa, Shaker A. ; Mukhtar, Hasan. / Introducing nanochemoprevention as a novel approach for cancer control : Proof of principle with green tea polyphenol epigallocatechin-3-gallate. In: Cancer Research. 2009 ; Vol. 69, No. 5. pp. 1712-1716.
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