Introduction

The brain-immune axis: Role of opiates and other substances of abuse, the hypothalmic-pituitary-adrenal axis and behavior

S. Malta, D. Saphier, D. Lysle, Burt Sharp

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The brain-immune axis is a highly complex and dynamic homeostatic mechanism. The effect of morphine, or other drugs of abuse, on this interactive system can have multiple consequences, depending on the specific site(s) of action, duration of exposure and underlying neuroendocrine, neural and behavioral status. This emphasizes the critical role of interdisciplinary studies, incorporating behavioral, pharmacological, neuroanatomical, cellular and molecular approaches, that are necessary for elucidating opiate-BIA interactions. To characterize fundamental mechanisms of action, the sheer complexity of this system often requires that more rigorous experimental methodology be applied by multidisciplinary groups of investigators than ever before.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalAdvances in Experimental Medicine and Biology
Volume373
StatePublished - Jan 1 1995

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Opiate Alkaloids
Interdisciplinary Studies
Street Drugs
Morphine
Substance-Related Disorders
Brain
Research Personnel
Pharmacology

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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