Investigation of type i and type iii collagens of the lung in progressive systemic sclerosis

Jerome M. Seyer, Andrew Kang, Gerald Rodnan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The interstitial collagens, type I and type III, were investigated in lung tissue from patients with progressive systemic sclerosis (PSS) with pulmonary involvement. By use of CNBr digestion of whole tissue, the relative content of type I versus type III collagen was unchanged. This contrasts with idiopathic pulmonary fibrosis. Limited pepsin digestion released greater amounts of collagen (55%) than normal (16%), but the individual collagen chains were chemically indistinguishable. A reduced amount of the more stable collagen crosslink, hydroxylysinonorleucine, was observed which was consistent with the relatively greater degree of solubilization.

Original languageEnglish (US)
Pages (from-to)625-631
Number of pages7
JournalArthritis & Rheumatism
Volume24
Issue number4
DOIs
StatePublished - Jan 1 1981

Fingerprint

Diffuse Scleroderma
Collagen
Lung
Digestion
Idiopathic Pulmonary Fibrosis
Collagen Type III
Pepsin A
Collagen Type I

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Investigation of type i and type iii collagens of the lung in progressive systemic sclerosis. / Seyer, Jerome M.; Kang, Andrew; Rodnan, Gerald.

In: Arthritis & Rheumatism, Vol. 24, No. 4, 01.01.1981, p. 625-631.

Research output: Contribution to journalArticle

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