Ion Channels

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The cell membrane facilitates the diffusion of nonpolar hydrophobic molecules between intracellular and extracellular compartments. Different cell types express unique assemblages of various ion channels, each of which allows for ions to pass down their electrochemical gradient until they reach their ionic equilibrium, defined by the Nernst equation. Ion channels are fundamental to cell existence and control a broad range of essential physiological processes, including nerve and muscle excitation, action potential generation and shaping, muscle contraction, sensory transduction, blood pressure regulation, cell proliferation, hormone secretion, learning and memory, cell volume regulation, fertilization, maintenance of salt and water balance, and cell death. Ion channels are found not only in the cell membrane but also in the membranes of the intracellular organelles such as mitochondria, lysozymes, nucleus, and secretory, endocytotic, and synaptic vesicles, as well as in the endoplasmic/sacroplasmic reticulum (ER/SR). A number of ion channel-specific compounds have recently been approved by the Food and Drug Administration (FDA) as therapeutics, and others are currently in various stages of clinical trials as potential drugs for a number of indications, including pain and cardiovascular and neurological pathologies. © 2009

Original languageEnglish (US)
Title of host publicationPharmacology
PublisherElsevier Inc.
Pages387-427
Number of pages41
ISBN (Print)9780123695215
DOIs
StatePublished - Dec 1 2009

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Ion Channels
Cell Membrane
Physiological Phenomena
Intracellular Membranes
Synaptic Vesicles
Secretory Vesicles
United States Food and Drug Administration
Muramidase
Muscle Contraction
Cell Size
Fertilization
Endoplasmic Reticulum
Organelles
Action Potentials
Mitochondria
Cell Death
Salts
Maintenance
Cell Proliferation
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Petkov, G. V. (2009). Ion Channels. In Pharmacology (pp. 387-427). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-369521-5.00016-6

Ion Channels. / Petkov, Georgi V.

Pharmacology. Elsevier Inc., 2009. p. 387-427.

Research output: Chapter in Book/Report/Conference proceedingChapter

Petkov, GV 2009, Ion Channels. in Pharmacology. Elsevier Inc., pp. 387-427. https://doi.org/10.1016/B978-0-12-369521-5.00016-6
Petkov GV. Ion Channels. In Pharmacology. Elsevier Inc. 2009. p. 387-427 https://doi.org/10.1016/B978-0-12-369521-5.00016-6
Petkov, Georgi V. / Ion Channels. Pharmacology. Elsevier Inc., 2009. pp. 387-427
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