Is there evidence of early vascular disease in patients with obstructive sleep apnoea without known comorbidities? Preliminary findings

P. Steiropoulos, C. Bogiatzi, K. Archontogeorgis, E. Nena, M. Xanthoudaki, P. Boglou, A. Tzouvelekis, N. Papanas, Georgios Tsivgoulis, D. Bouros

Research output: Contribution to journalArticle

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Abstract

We evaluated early atherosclerotic lesions in 20 non-smokers with newly diagnosed Obstructive Sleep Apnoea (OSA) and without known comorbidities by measuring common carotid artery intima media thickness (CCA-IMT), transcranial Doppler ultrasound (TCD), and ankle brachial index (ABI). These were compared with 20 healthy age- and BMImatched controls. In OSA patients, CCA-IMT was not significantly higher vs. controls (0.74±0.17 vs. 0.66±0.12 mm, p=0.201) and it was positively correlated with neck circumference (r=0.466, p=0.039), arousal index (r=0.663, p=0.001), gamma-glutamyl transpeptidase activity (r=0.474, p=0.035) while it was negatively correlated with Forced Expiratory Volume in 1 sec (r=-0.055, p=0.012). No difference was noted between patients and controls in terms of vascular stenosis on TCD examination, while asymptomatic peripheral artery disease was found in one patient with OSA. In conclusion, OSA patients without known comorbidities exhibit a non-significant increase in CCA-IMT without further evidence of vascular disease, but additional experience in a larger patient series is needed.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalOpen Cardiovascular Medicine Journal
Volume7
Issue number1
StatePublished - Sep 20 2013

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Obstructive Sleep Apnea
Vascular Diseases
Comorbidity
Carotid Intima-Media Thickness
Common Carotid Artery
Doppler Ultrasonography
Ankle Brachial Index
gamma-Glutamyltransferase
Peripheral Arterial Disease
Forced Expiratory Volume
Arousal
Blood Vessels
Pathologic Constriction
Neck

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Steiropoulos, P., Bogiatzi, C., Archontogeorgis, K., Nena, E., Xanthoudaki, M., Boglou, P., ... Bouros, D. (2013). Is there evidence of early vascular disease in patients with obstructive sleep apnoea without known comorbidities? Preliminary findings. Open Cardiovascular Medicine Journal, 7(1), 61-68.

Is there evidence of early vascular disease in patients with obstructive sleep apnoea without known comorbidities? Preliminary findings. / Steiropoulos, P.; Bogiatzi, C.; Archontogeorgis, K.; Nena, E.; Xanthoudaki, M.; Boglou, P.; Tzouvelekis, A.; Papanas, N.; Tsivgoulis, Georgios; Bouros, D.

In: Open Cardiovascular Medicine Journal, Vol. 7, No. 1, 20.09.2013, p. 61-68.

Research output: Contribution to journalArticle

Steiropoulos, P, Bogiatzi, C, Archontogeorgis, K, Nena, E, Xanthoudaki, M, Boglou, P, Tzouvelekis, A, Papanas, N, Tsivgoulis, G & Bouros, D 2013, 'Is there evidence of early vascular disease in patients with obstructive sleep apnoea without known comorbidities? Preliminary findings', Open Cardiovascular Medicine Journal, vol. 7, no. 1, pp. 61-68.
Steiropoulos, P. ; Bogiatzi, C. ; Archontogeorgis, K. ; Nena, E. ; Xanthoudaki, M. ; Boglou, P. ; Tzouvelekis, A. ; Papanas, N. ; Tsivgoulis, Georgios ; Bouros, D. / Is there evidence of early vascular disease in patients with obstructive sleep apnoea without known comorbidities? Preliminary findings. In: Open Cardiovascular Medicine Journal. 2013 ; Vol. 7, No. 1. pp. 61-68.
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