Ischemic myocardial protection. Comparison of nonoxygenated crystalloid, oxygenated crystalloid, and oxygenated fluorocarbon cardioplegic solutions

K. Tabayashi, Peter Mckeown, M. Miyamoto, A. E. Luedtke, R. Thomas, M. D. Allen, G. A. Misbach, T. D. Ivey

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study was designed to compare myocardial protection with a nonoxygenated crystalloid solution, an oxygenated crystalloid solution, and an oxygenated fluorocarbon cardioplegic solution. Postischemic ventricular performance was studied in three equal (N = 7) groups of dogs subjected to 120 minutes of global ischemia induced at an average myocardial temperature of 18.5° ± 1.4° C (range 17.0° to 21.1° C). Left ventricular global and regional function was evaluated by sonomicrometry and micromanometers before ischemia and at 45 and 60 minutes after ischemia. Stroke volume index, left ventricular pressure-minor external diameter loop area, percent shortening, first derivative of left ventricular pressure, mean velocity of circumferential fiber shortening, and the slope of the end-systolic pressure were used to evaluate myocardial contractility. In vitro oxygen content of the three cardioplegic solutions was measured at a mean injection temperature of 8.3° ± 0.6° C: 0.8 ± 0.1 vol% (nonoxygenated crystalloid cardioplegia), 3.2 ± 0.2 vol% (oxygenated crystalloid cardioplegia), and 6.2 ± 0.2 vol% (oxygenated fluorocarbon cardioplegia). Recovery of global and regional function was significantly (p < 0.05) better with both oxygenated solutions than with the nonoxygenated solution. Differences between the oxygenated crystalloid and fluorocarbon groups were not significant. We conclude: (1) Compared to nonoxygenated crystalloid cardioplegia, oxygenated crystalloid and oxygenated fluorocarbon cardioplegic solutions gave superior myocardial protection during 2 hours of ischemic arrest; (2) no difference was found in protective effects between an oxygenated crystalloid and an oxygenated fluorocarbon solution.

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume95
Issue number2
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Cardioplegic Solutions
Fluorocarbons
Induced Heart Arrest
Ischemia
Ventricular Pressure
Temperature
crystalloid solutions
Stroke Volume
Dogs
Oxygen
Blood Pressure
Injections

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Ischemic myocardial protection. Comparison of nonoxygenated crystalloid, oxygenated crystalloid, and oxygenated fluorocarbon cardioplegic solutions. / Tabayashi, K.; Mckeown, Peter; Miyamoto, M.; Luedtke, A. E.; Thomas, R.; Allen, M. D.; Misbach, G. A.; Ivey, T. D.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 95, No. 2, 01.01.1988, p. 239-246.

Research output: Contribution to journalArticle

Tabayashi, K. ; Mckeown, Peter ; Miyamoto, M. ; Luedtke, A. E. ; Thomas, R. ; Allen, M. D. ; Misbach, G. A. ; Ivey, T. D. / Ischemic myocardial protection. Comparison of nonoxygenated crystalloid, oxygenated crystalloid, and oxygenated fluorocarbon cardioplegic solutions. In: Journal of Thoracic and Cardiovascular Surgery. 1988 ; Vol. 95, No. 2. pp. 239-246.
@article{c068baa67af84b4b9daad30b34f52857,
title = "Ischemic myocardial protection. Comparison of nonoxygenated crystalloid, oxygenated crystalloid, and oxygenated fluorocarbon cardioplegic solutions",
abstract = "This study was designed to compare myocardial protection with a nonoxygenated crystalloid solution, an oxygenated crystalloid solution, and an oxygenated fluorocarbon cardioplegic solution. Postischemic ventricular performance was studied in three equal (N = 7) groups of dogs subjected to 120 minutes of global ischemia induced at an average myocardial temperature of 18.5° ± 1.4° C (range 17.0° to 21.1° C). Left ventricular global and regional function was evaluated by sonomicrometry and micromanometers before ischemia and at 45 and 60 minutes after ischemia. Stroke volume index, left ventricular pressure-minor external diameter loop area, percent shortening, first derivative of left ventricular pressure, mean velocity of circumferential fiber shortening, and the slope of the end-systolic pressure were used to evaluate myocardial contractility. In vitro oxygen content of the three cardioplegic solutions was measured at a mean injection temperature of 8.3° ± 0.6° C: 0.8 ± 0.1 vol{\%} (nonoxygenated crystalloid cardioplegia), 3.2 ± 0.2 vol{\%} (oxygenated crystalloid cardioplegia), and 6.2 ± 0.2 vol{\%} (oxygenated fluorocarbon cardioplegia). Recovery of global and regional function was significantly (p < 0.05) better with both oxygenated solutions than with the nonoxygenated solution. Differences between the oxygenated crystalloid and fluorocarbon groups were not significant. We conclude: (1) Compared to nonoxygenated crystalloid cardioplegia, oxygenated crystalloid and oxygenated fluorocarbon cardioplegic solutions gave superior myocardial protection during 2 hours of ischemic arrest; (2) no difference was found in protective effects between an oxygenated crystalloid and an oxygenated fluorocarbon solution.",
author = "K. Tabayashi and Peter Mckeown and M. Miyamoto and Luedtke, {A. E.} and R. Thomas and Allen, {M. D.} and Misbach, {G. A.} and Ivey, {T. D.}",
year = "1988",
month = "1",
day = "1",
language = "English (US)",
volume = "95",
pages = "239--246",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Ischemic myocardial protection. Comparison of nonoxygenated crystalloid, oxygenated crystalloid, and oxygenated fluorocarbon cardioplegic solutions

AU - Tabayashi, K.

AU - Mckeown, Peter

AU - Miyamoto, M.

AU - Luedtke, A. E.

AU - Thomas, R.

AU - Allen, M. D.

AU - Misbach, G. A.

AU - Ivey, T. D.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - This study was designed to compare myocardial protection with a nonoxygenated crystalloid solution, an oxygenated crystalloid solution, and an oxygenated fluorocarbon cardioplegic solution. Postischemic ventricular performance was studied in three equal (N = 7) groups of dogs subjected to 120 minutes of global ischemia induced at an average myocardial temperature of 18.5° ± 1.4° C (range 17.0° to 21.1° C). Left ventricular global and regional function was evaluated by sonomicrometry and micromanometers before ischemia and at 45 and 60 minutes after ischemia. Stroke volume index, left ventricular pressure-minor external diameter loop area, percent shortening, first derivative of left ventricular pressure, mean velocity of circumferential fiber shortening, and the slope of the end-systolic pressure were used to evaluate myocardial contractility. In vitro oxygen content of the three cardioplegic solutions was measured at a mean injection temperature of 8.3° ± 0.6° C: 0.8 ± 0.1 vol% (nonoxygenated crystalloid cardioplegia), 3.2 ± 0.2 vol% (oxygenated crystalloid cardioplegia), and 6.2 ± 0.2 vol% (oxygenated fluorocarbon cardioplegia). Recovery of global and regional function was significantly (p < 0.05) better with both oxygenated solutions than with the nonoxygenated solution. Differences between the oxygenated crystalloid and fluorocarbon groups were not significant. We conclude: (1) Compared to nonoxygenated crystalloid cardioplegia, oxygenated crystalloid and oxygenated fluorocarbon cardioplegic solutions gave superior myocardial protection during 2 hours of ischemic arrest; (2) no difference was found in protective effects between an oxygenated crystalloid and an oxygenated fluorocarbon solution.

AB - This study was designed to compare myocardial protection with a nonoxygenated crystalloid solution, an oxygenated crystalloid solution, and an oxygenated fluorocarbon cardioplegic solution. Postischemic ventricular performance was studied in three equal (N = 7) groups of dogs subjected to 120 minutes of global ischemia induced at an average myocardial temperature of 18.5° ± 1.4° C (range 17.0° to 21.1° C). Left ventricular global and regional function was evaluated by sonomicrometry and micromanometers before ischemia and at 45 and 60 minutes after ischemia. Stroke volume index, left ventricular pressure-minor external diameter loop area, percent shortening, first derivative of left ventricular pressure, mean velocity of circumferential fiber shortening, and the slope of the end-systolic pressure were used to evaluate myocardial contractility. In vitro oxygen content of the three cardioplegic solutions was measured at a mean injection temperature of 8.3° ± 0.6° C: 0.8 ± 0.1 vol% (nonoxygenated crystalloid cardioplegia), 3.2 ± 0.2 vol% (oxygenated crystalloid cardioplegia), and 6.2 ± 0.2 vol% (oxygenated fluorocarbon cardioplegia). Recovery of global and regional function was significantly (p < 0.05) better with both oxygenated solutions than with the nonoxygenated solution. Differences between the oxygenated crystalloid and fluorocarbon groups were not significant. We conclude: (1) Compared to nonoxygenated crystalloid cardioplegia, oxygenated crystalloid and oxygenated fluorocarbon cardioplegic solutions gave superior myocardial protection during 2 hours of ischemic arrest; (2) no difference was found in protective effects between an oxygenated crystalloid and an oxygenated fluorocarbon solution.

UR - http://www.scopus.com/inward/record.url?scp=0023902996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023902996&partnerID=8YFLogxK

M3 - Article

VL - 95

SP - 239

EP - 246

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

SN - 0022-5223

IS - 2

ER -