Isolate housing alters ethanol sensitivity in long-sleep and short-sleep mice

Byron Jones, Joan M. Connell, V. Gene Erwin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Beginning at 45 days of age, male long-sleep (LS) and short-sleep (SS) mice were placed into individual cages for 21-22 days. Control animals were group-housed for the same amount of time. At 65-66 days of age, animals were given anesthetic doses of ethanol, IP. Measures taken were sleep time, body temperature at 30 and 60 minutes postinjection and blood ethanol content (BEC) at regain of righting response. Compared to the same measures in group-housed animals, sleep times and hypothermia were attenuated in isolate-housed LS and SS mice. Isolate housing resulted in a 15% increase, compared to levels observed in group-housed animals, in BEC at regain of righting in LS; there was no significant difference in BEC in SS mice. The results indicated an isolation-related decrease in sensitivity to the anesthetic effects of ethanol in LS; the effect of isolation in SS may be an increased clearance rate of ethanol.

Original languageEnglish (US)
Pages (from-to)469-472
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume35
Issue number2
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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Sleep
Ethanol
Animals
Regain
Blood
Anesthetics
Hypothermia
Righting Reflex
Body Temperature

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Isolate housing alters ethanol sensitivity in long-sleep and short-sleep mice. / Jones, Byron; Connell, Joan M.; Gene Erwin, V.

In: Pharmacology, Biochemistry and Behavior, Vol. 35, No. 2, 01.01.1990, p. 469-472.

Research output: Contribution to journalArticle

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