Isolated Optic Nerve Glioma in Children With and Without Neurofibromatosis

Retrospective Characterization and Analysis of Outcomes

Dima Hamideh, Mary Ellen Hoehn, Julie H. Harreld, Paul Klimo, Amar Gajjar, Ibrahim Qaddoumi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Isolated optic nerve glioma is a rare tumor with no consensus for the best therapeutic approach. Therefore, tumor control and preservation of visual function remain a challenge. In this retrospective study, we describe our experience over 30 years in a single-institutional cohort of children with isolated optic nerve glioma, focusing on treatments and visual outcomes. Seventeen children were followed for a median period of 8 years (range, 2-22 years). Diagnosis was based on typical neuroradiologic findings, and 3 patients had histologic confirmation of their tumors. In our study, conservative management preserved the vision of most patients with neurofibromatosis type 1 (NF1). NF1-related optic nerve gliomas were less often treated but were associated with a lower probability of progression and with occasional spontaneous regression. Sporadic tumors more frequently exhibited aggressive clinical behavior with a higher propensity for posterior extension, often requiring surgical intervention.

Original languageEnglish (US)
Pages (from-to)375-382
Number of pages8
JournalJournal of child neurology
Volume33
Issue number6
DOIs
StatePublished - May 1 2018

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Optic Nerve Glioma
Neurofibromatoses
Neurofibromatosis 1
Neoplasms
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Isolated Optic Nerve Glioma in Children With and Without Neurofibromatosis : Retrospective Characterization and Analysis of Outcomes. / Hamideh, Dima; Hoehn, Mary Ellen; Harreld, Julie H.; Klimo, Paul; Gajjar, Amar; Qaddoumi, Ibrahim.

In: Journal of child neurology, Vol. 33, No. 6, 01.05.2018, p. 375-382.

Research output: Contribution to journalArticle

Hamideh, Dima ; Hoehn, Mary Ellen ; Harreld, Julie H. ; Klimo, Paul ; Gajjar, Amar ; Qaddoumi, Ibrahim. / Isolated Optic Nerve Glioma in Children With and Without Neurofibromatosis : Retrospective Characterization and Analysis of Outcomes. In: Journal of child neurology. 2018 ; Vol. 33, No. 6. pp. 375-382.
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