Isoniazid-induced alterations in theophylline pharmacokinetics

J. R. Thompson, G. J. Burckart, T. H. Self

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Administration of an oral dose of isoniazid (300 mg) for six consecutive nights increased the mean oral theophylline clearance by 16% in four healthy male subjects. No consistent differences were noted in maximal plasma concentration (Cmax), time of maximal plasma concentration (Tmax), elimination half-life (t 1/2 ), absorption rate constant (ka), elimination rate constant (ke), area under the curve (AUC), or apparent volume of distribution (Vd). Although isoniazid is a well-documented inhibitor of the metabolism of many drugs, its effect upon theophylline appears to be one of increased metabolism either by enzyme induction or an unknown mechanism.

Original languageEnglish (US)
Pages (from-to)921-925
Number of pages5
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume32
Issue number6 I
StatePublished - Jan 1 1982

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Isoniazid
Theophylline
Pharmacokinetics
Enzyme Induction
Area Under Curve
Oral Administration
Half-Life
Healthy Volunteers
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Isoniazid-induced alterations in theophylline pharmacokinetics. / Thompson, J. R.; Burckart, G. J.; Self, T. H.

In: Current Therapeutic Research - Clinical and Experimental, Vol. 32, No. 6 I, 01.01.1982, p. 921-925.

Research output: Contribution to journalArticle

Thompson, JR, Burckart, GJ & Self, TH 1982, 'Isoniazid-induced alterations in theophylline pharmacokinetics', Current Therapeutic Research - Clinical and Experimental, vol. 32, no. 6 I, pp. 921-925.
Thompson, J. R. ; Burckart, G. J. ; Self, T. H. / Isoniazid-induced alterations in theophylline pharmacokinetics. In: Current Therapeutic Research - Clinical and Experimental. 1982 ; Vol. 32, No. 6 I. pp. 921-925.
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