Isotope incorporation using organoboranes

George W. Kabalka, Min Liang Yao, Murthy Akula, Li Yong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Isotopes have played an important role in chemistry, biology, and medicine. For the last three decades, we have focused on the use of organoboron compounds as precursors to isotopically labeled physiologically active reagents. During that period, we have successfully developed methods for incorporating short- and long-lived isotopes of carbon, nitrogen, oxygen, and the halogens using a variety of reactive organoboron precursors. In addition, labeling strategies employing polymer-supported organoboron derivatives were developed. In this report, we present a short overview focused on the evolution of radiolabeling techniques based on boron chemistry.

Original languageEnglish (US)
Pages (from-to)2309-2315
Number of pages7
JournalPure and Applied Chemistry
Volume84
Issue number11
DOIs
StatePublished - Nov 6 2012

Fingerprint

Isotopes
Carbon Isotopes
Halogens
Boron
Labeling
Medicine
Polymers
Nitrogen
Oxygen
Derivatives
Carbon

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Isotope incorporation using organoboranes. / Kabalka, George W.; Yao, Min Liang; Akula, Murthy; Yong, Li.

In: Pure and Applied Chemistry, Vol. 84, No. 11, 06.11.2012, p. 2309-2315.

Research output: Contribution to journalArticle

Kabalka, George W. ; Yao, Min Liang ; Akula, Murthy ; Yong, Li. / Isotope incorporation using organoboranes. In: Pure and Applied Chemistry. 2012 ; Vol. 84, No. 11. pp. 2309-2315.
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