Issues & opinion. Sporadic ALS and chromosome 22

Evidence for a possible neurofilament gene defect

Michael A. Meyer, Nicholas Potter

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

ALS is associated with the P2 blood group phenotype. Molecular evidence now shows the gene encoding this antigen to be on the long arm of human chromosome 22 near the newly discovered gene for heavy neurofilament (NF‐H). Since an ALS‐type condition can be generated in transgenic mice expressing the human NF‐H gene, and since the gene for the CNTF‐related cytokine leukemia inhibitory factor (LIF) is located adjacent to this gene, it is hypothesized that a defect on the chromosome 22 band region q12 is involved in the pathogenesis of sporadic ALS. © 1995 John Wiley & Sons, Inc.

Original languageEnglish (US)
Pages (from-to)536-539
Number of pages4
JournalMuscle & Nerve
Volume18
Issue number5
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 22
Intermediate Filaments
Genes
Leukemia Inhibitory Factor
Human Chromosomes
Blood Group Antigens
Transgenic Mice
Cytokines
Phenotype
Antigens

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Issues & opinion. Sporadic ALS and chromosome 22 : Evidence for a possible neurofilament gene defect. / Meyer, Michael A.; Potter, Nicholas.

In: Muscle & Nerve, Vol. 18, No. 5, 01.01.1995, p. 536-539.

Research output: Contribution to journalArticle

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