Issues of adherence to immunosuppressant therapy after solid-organ transplantation

Research output: Contribution to journalReview article

65 Citations (Scopus)

Abstract

Nonadherence to immunosuppressant therapy constitutes a major barrier to post-transplant care. Failure of transplant recipients to take prescribed drugs properly may not only be a significant obstacle to optimal graft function but it may also result in decreased quality of life and productivity, increased morbidity and healthcare cost, and death. Despite the obvious importance of adherence to immunosuppressant therapy, nonadherence is frequent among transplant recipients, with rates ranging from 2 to 68%. This manuscript briefly discusses several issues concerning adherence to immunosuppressant therapy of solid-organ transplant recipients; presents a literature review concerning adherence to immunosuppressant therapy by solid-organ transplant recipients; and suggests strategies that may be used to enhance medication adherence. Although many of the studies have results that conflict concerning factors associated with immunosuppressive nonadherence, most of the investigators concluded that nonadherent behaviour is usually not predictable. Because of possible adverse events, emphasis should be placed on increasing medication adherence in all transplant recipients.

Original languageEnglish (US)
Pages (from-to)567-575
Number of pages9
JournalDrugs
Volume62
Issue number4
DOIs
StatePublished - Jan 1 2002

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Organ Transplantation
Immunosuppressive Agents
Transplants
Medication Adherence
Therapeutics
Health Care Costs
Quality of Life
Research Personnel
Transplant Recipients
Morbidity
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Issues of adherence to immunosuppressant therapy after solid-organ transplantation. / Chisholm-Burns, Marie.

In: Drugs, Vol. 62, No. 4, 01.01.2002, p. 567-575.

Research output: Contribution to journalReview article

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