Keratinocyte growth factor accelerates wound closure of airway epithelium during cyclic strain

C. M. Waters, U. Savla

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Wound closure was investigated using primary cultures of cat tracheal epithelium (CTE), normal human bronchial airway epithelial cells (NHBE), and a cell line of human airway epithelial cells (Calu 3). CTE wound closure in the periphery and in the center of unstretched wells was identical, but wound closure in the periphery and in the center of wells subjected to cyclic strain was inhibited. Similar results were obtained for NHBE and Calu 3 cells. Cyclic elongation and cyclic compression inhibited overall epithelial wound closure in vitro. Furthermore, keratinocyte growth factor significantly accelerated wound closure and overcame the inhibitory effects of cyclic strain.

Original languageEnglish (US)
Title of host publicationSouthern Biomedical Engineering Conference - Proceedings
PublisherIEEE
Pages99
Number of pages1
StatePublished - 1998
Externally publishedYes
EventProceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA
Duration: Feb 6 1998Feb 8 1998

Other

OtherProceedings of the 1998 17th Southern Biomedical Engineering Conference
CitySan Antonio, TX, USA
Period2/6/982/8/98

Fingerprint

Elongation
Cells
Intercellular Signaling Peptides and Proteins
Keratinocytes
Epithelial Cells

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Waters, C. M., & Savla, U. (1998). Keratinocyte growth factor accelerates wound closure of airway epithelium during cyclic strain. In Southern Biomedical Engineering Conference - Proceedings (pp. 99). IEEE.

Keratinocyte growth factor accelerates wound closure of airway epithelium during cyclic strain. / Waters, C. M.; Savla, U.

Southern Biomedical Engineering Conference - Proceedings. IEEE, 1998. p. 99.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Waters, CM & Savla, U 1998, Keratinocyte growth factor accelerates wound closure of airway epithelium during cyclic strain. in Southern Biomedical Engineering Conference - Proceedings. IEEE, pp. 99, Proceedings of the 1998 17th Southern Biomedical Engineering Conference, San Antonio, TX, USA, 2/6/98.
Waters CM, Savla U. Keratinocyte growth factor accelerates wound closure of airway epithelium during cyclic strain. In Southern Biomedical Engineering Conference - Proceedings. IEEE. 1998. p. 99
Waters, C. M. ; Savla, U. / Keratinocyte growth factor accelerates wound closure of airway epithelium during cyclic strain. Southern Biomedical Engineering Conference - Proceedings. IEEE, 1998. pp. 99
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