Kidney function as a predictor of loss of lean mass in older adults: Health, aging and body composition study

Linda F. Fried, Robert Boudreau, Jung Sun Lee, Glenn Chertow, Manjula Kurella-Tamura, Michael G. Shlipak, Jingzhong Ding, Deborah Sellmeyer, Frances A. Tylavsky, Eleanor Simsonick, Stephen B. Kritchevsky, Tamara B. Harris, Anne B. Newman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

OBJECTIVES: To assess the association between kidney function and change in body composition in older individuals. DESIGN: Prospective cohort study. SETTING: Two sites, Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Three thousand twenty-six well-functioning, participants aged 70 to 79 in the Health, Aging and Body Composition Study. MEASUREMENTS: Body composition (bone-free lean mass and fat mass) was measured using dual x-ray absorptiometry annually for 4 years. Kidney function was measured at baseline according to serum creatinine (SCr). Comorbidity and inflammatory markers were evaluated as covariates in mixed-model, repeated-measures analysis. RESULTS: High SCr was associated with loss of lean mass in men but not women, with a stronger relationship in black men (P=.02 for difference between slopes for white and black men). In white men, after adjustment for age and comorbidity, higher SCr remained associated with loss of lean mass (-0.07±0.03 kg/y greater loss per 0.4 mg/dL (1 standard deviation (SD)), P=.009) but was attenuated after adjustment for inflammatory factors (-0.05±0.03 kg/y greater loss per SD, P=.10). In black men, the relationship between SCr and loss of lean mass (-0.19±0.04 kg/y per SD, P<.001) persisted after adjustment for inflammation and overall weight change. CONCLUSION: Impaired kidney function may contribute to loss of lean mass in older men. Inflammation appeared to mediate the relationship in white but not black men. Future studies should strive to elucidate mechanisms linking kidney disease and muscle loss and identify treatments to minimize loss of lean mass and its functional consequences.

Original languageEnglish (US)
Pages (from-to)1578-1584
Number of pages7
JournalJournal of the American Geriatrics Society
Volume55
Issue number10
DOIs
StatePublished - Oct 1 2007

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Body Composition
Kidney
Health
Creatinine
Serum
Comorbidity
Inflammation
Kidney Diseases
Cohort Studies
Fats
X-Rays
Prospective Studies
Weights and Measures
Bone and Bones
Muscles

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Fried, L. F., Boudreau, R., Lee, J. S., Chertow, G., Kurella-Tamura, M., Shlipak, M. G., ... Newman, A. B. (2007). Kidney function as a predictor of loss of lean mass in older adults: Health, aging and body composition study. Journal of the American Geriatrics Society, 55(10), 1578-1584. https://doi.org/10.1111/j.1532-5415.2007.01398.x

Kidney function as a predictor of loss of lean mass in older adults : Health, aging and body composition study. / Fried, Linda F.; Boudreau, Robert; Lee, Jung Sun; Chertow, Glenn; Kurella-Tamura, Manjula; Shlipak, Michael G.; Ding, Jingzhong; Sellmeyer, Deborah; Tylavsky, Frances A.; Simsonick, Eleanor; Kritchevsky, Stephen B.; Harris, Tamara B.; Newman, Anne B.

In: Journal of the American Geriatrics Society, Vol. 55, No. 10, 01.10.2007, p. 1578-1584.

Research output: Contribution to journalArticle

Fried, LF, Boudreau, R, Lee, JS, Chertow, G, Kurella-Tamura, M, Shlipak, MG, Ding, J, Sellmeyer, D, Tylavsky, FA, Simsonick, E, Kritchevsky, SB, Harris, TB & Newman, AB 2007, 'Kidney function as a predictor of loss of lean mass in older adults: Health, aging and body composition study', Journal of the American Geriatrics Society, vol. 55, no. 10, pp. 1578-1584. https://doi.org/10.1111/j.1532-5415.2007.01398.x
Fried, Linda F. ; Boudreau, Robert ; Lee, Jung Sun ; Chertow, Glenn ; Kurella-Tamura, Manjula ; Shlipak, Michael G. ; Ding, Jingzhong ; Sellmeyer, Deborah ; Tylavsky, Frances A. ; Simsonick, Eleanor ; Kritchevsky, Stephen B. ; Harris, Tamara B. ; Newman, Anne B. / Kidney function as a predictor of loss of lean mass in older adults : Health, aging and body composition study. In: Journal of the American Geriatrics Society. 2007 ; Vol. 55, No. 10. pp. 1578-1584.
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abstract = "OBJECTIVES: To assess the association between kidney function and change in body composition in older individuals. DESIGN: Prospective cohort study. SETTING: Two sites, Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Three thousand twenty-six well-functioning, participants aged 70 to 79 in the Health, Aging and Body Composition Study. MEASUREMENTS: Body composition (bone-free lean mass and fat mass) was measured using dual x-ray absorptiometry annually for 4 years. Kidney function was measured at baseline according to serum creatinine (SCr). Comorbidity and inflammatory markers were evaluated as covariates in mixed-model, repeated-measures analysis. RESULTS: High SCr was associated with loss of lean mass in men but not women, with a stronger relationship in black men (P=.02 for difference between slopes for white and black men). In white men, after adjustment for age and comorbidity, higher SCr remained associated with loss of lean mass (-0.07±0.03 kg/y greater loss per 0.4 mg/dL (1 standard deviation (SD)), P=.009) but was attenuated after adjustment for inflammatory factors (-0.05±0.03 kg/y greater loss per SD, P=.10). In black men, the relationship between SCr and loss of lean mass (-0.19±0.04 kg/y per SD, P<.001) persisted after adjustment for inflammation and overall weight change. CONCLUSION: Impaired kidney function may contribute to loss of lean mass in older men. Inflammation appeared to mediate the relationship in white but not black men. Future studies should strive to elucidate mechanisms linking kidney disease and muscle loss and identify treatments to minimize loss of lean mass and its functional consequences.",
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AU - Fried, Linda F.

AU - Boudreau, Robert

AU - Lee, Jung Sun

AU - Chertow, Glenn

AU - Kurella-Tamura, Manjula

AU - Shlipak, Michael G.

AU - Ding, Jingzhong

AU - Sellmeyer, Deborah

AU - Tylavsky, Frances A.

AU - Simsonick, Eleanor

AU - Kritchevsky, Stephen B.

AU - Harris, Tamara B.

AU - Newman, Anne B.

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N2 - OBJECTIVES: To assess the association between kidney function and change in body composition in older individuals. DESIGN: Prospective cohort study. SETTING: Two sites, Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Three thousand twenty-six well-functioning, participants aged 70 to 79 in the Health, Aging and Body Composition Study. MEASUREMENTS: Body composition (bone-free lean mass and fat mass) was measured using dual x-ray absorptiometry annually for 4 years. Kidney function was measured at baseline according to serum creatinine (SCr). Comorbidity and inflammatory markers were evaluated as covariates in mixed-model, repeated-measures analysis. RESULTS: High SCr was associated with loss of lean mass in men but not women, with a stronger relationship in black men (P=.02 for difference between slopes for white and black men). In white men, after adjustment for age and comorbidity, higher SCr remained associated with loss of lean mass (-0.07±0.03 kg/y greater loss per 0.4 mg/dL (1 standard deviation (SD)), P=.009) but was attenuated after adjustment for inflammatory factors (-0.05±0.03 kg/y greater loss per SD, P=.10). In black men, the relationship between SCr and loss of lean mass (-0.19±0.04 kg/y per SD, P<.001) persisted after adjustment for inflammation and overall weight change. CONCLUSION: Impaired kidney function may contribute to loss of lean mass in older men. Inflammation appeared to mediate the relationship in white but not black men. Future studies should strive to elucidate mechanisms linking kidney disease and muscle loss and identify treatments to minimize loss of lean mass and its functional consequences.

AB - OBJECTIVES: To assess the association between kidney function and change in body composition in older individuals. DESIGN: Prospective cohort study. SETTING: Two sites, Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Three thousand twenty-six well-functioning, participants aged 70 to 79 in the Health, Aging and Body Composition Study. MEASUREMENTS: Body composition (bone-free lean mass and fat mass) was measured using dual x-ray absorptiometry annually for 4 years. Kidney function was measured at baseline according to serum creatinine (SCr). Comorbidity and inflammatory markers were evaluated as covariates in mixed-model, repeated-measures analysis. RESULTS: High SCr was associated with loss of lean mass in men but not women, with a stronger relationship in black men (P=.02 for difference between slopes for white and black men). In white men, after adjustment for age and comorbidity, higher SCr remained associated with loss of lean mass (-0.07±0.03 kg/y greater loss per 0.4 mg/dL (1 standard deviation (SD)), P=.009) but was attenuated after adjustment for inflammatory factors (-0.05±0.03 kg/y greater loss per SD, P=.10). In black men, the relationship between SCr and loss of lean mass (-0.19±0.04 kg/y per SD, P<.001) persisted after adjustment for inflammation and overall weight change. CONCLUSION: Impaired kidney function may contribute to loss of lean mass in older men. Inflammation appeared to mediate the relationship in white but not black men. Future studies should strive to elucidate mechanisms linking kidney disease and muscle loss and identify treatments to minimize loss of lean mass and its functional consequences.

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