K+ and Mg2+ Dyshomeostasis in Acute Hyperadrenergic Stressor States

Mannu Nayyar, Jawwad Yusuf, M. Usman Khan, Karl Weber

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Acute stressor states are linked to neurohormonal activation that includes the adrenergic nervous system. Elevations in circulating epinephrine and norepinephrine unmask an interdependency that exists between K+ and Mg2+ based on their regulation of a large number of Mg2+-dependent Na+/K+-ATPase pumps present in skeletal muscle. The hyperadrenergic state accounts for a sudden translocation of cations into muscle with the rapid appearance of hypokalemia and hypomagnesemia. The resultant hypokalemia and hypomagnesemia will cause a delay in myocardial repolarization and electrocardiographic QTc prolongation raising the propensity for supraventricular and ventricular arrhythmias. In this review, we focus on the interdependency between K+ and Mg2+, which is clinically relevant to acute hyperadrenergic stressor states found in patients admitted to intensive care units.

Original languageEnglish (US)
JournalAmerican Journal of the Medical Sciences
DOIs
StateAccepted/In press - Dec 6 2016

Fingerprint

Hypokalemia
Adrenergic Agents
Nervous System
Epinephrine
Intensive Care Units
Cations
Cardiac Arrhythmias
Norepinephrine
Skeletal Muscle
Muscles
sodium-translocating ATPase

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

K+ and Mg2+ Dyshomeostasis in Acute Hyperadrenergic Stressor States. / Nayyar, Mannu; Yusuf, Jawwad; Khan, M. Usman; Weber, Karl.

In: American Journal of the Medical Sciences, 06.12.2016.

Research output: Contribution to journalArticle

@article{b6aa30e81e9549a4afb3506799f39136,
title = "K+ and Mg2+ Dyshomeostasis in Acute Hyperadrenergic Stressor States",
abstract = "Acute stressor states are linked to neurohormonal activation that includes the adrenergic nervous system. Elevations in circulating epinephrine and norepinephrine unmask an interdependency that exists between K+ and Mg2+ based on their regulation of a large number of Mg2+-dependent Na+/K+-ATPase pumps present in skeletal muscle. The hyperadrenergic state accounts for a sudden translocation of cations into muscle with the rapid appearance of hypokalemia and hypomagnesemia. The resultant hypokalemia and hypomagnesemia will cause a delay in myocardial repolarization and electrocardiographic QTc prolongation raising the propensity for supraventricular and ventricular arrhythmias. In this review, we focus on the interdependency between K+ and Mg2+, which is clinically relevant to acute hyperadrenergic stressor states found in patients admitted to intensive care units.",
author = "Mannu Nayyar and Jawwad Yusuf and Khan, {M. Usman} and Karl Weber",
year = "2016",
month = "12",
day = "6",
doi = "10.1016/j.amjms.2017.01.001",
language = "English (US)",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - K+ and Mg2+ Dyshomeostasis in Acute Hyperadrenergic Stressor States

AU - Nayyar, Mannu

AU - Yusuf, Jawwad

AU - Khan, M. Usman

AU - Weber, Karl

PY - 2016/12/6

Y1 - 2016/12/6

N2 - Acute stressor states are linked to neurohormonal activation that includes the adrenergic nervous system. Elevations in circulating epinephrine and norepinephrine unmask an interdependency that exists between K+ and Mg2+ based on their regulation of a large number of Mg2+-dependent Na+/K+-ATPase pumps present in skeletal muscle. The hyperadrenergic state accounts for a sudden translocation of cations into muscle with the rapid appearance of hypokalemia and hypomagnesemia. The resultant hypokalemia and hypomagnesemia will cause a delay in myocardial repolarization and electrocardiographic QTc prolongation raising the propensity for supraventricular and ventricular arrhythmias. In this review, we focus on the interdependency between K+ and Mg2+, which is clinically relevant to acute hyperadrenergic stressor states found in patients admitted to intensive care units.

AB - Acute stressor states are linked to neurohormonal activation that includes the adrenergic nervous system. Elevations in circulating epinephrine and norepinephrine unmask an interdependency that exists between K+ and Mg2+ based on their regulation of a large number of Mg2+-dependent Na+/K+-ATPase pumps present in skeletal muscle. The hyperadrenergic state accounts for a sudden translocation of cations into muscle with the rapid appearance of hypokalemia and hypomagnesemia. The resultant hypokalemia and hypomagnesemia will cause a delay in myocardial repolarization and electrocardiographic QTc prolongation raising the propensity for supraventricular and ventricular arrhythmias. In this review, we focus on the interdependency between K+ and Mg2+, which is clinically relevant to acute hyperadrenergic stressor states found in patients admitted to intensive care units.

UR - http://www.scopus.com/inward/record.url?scp=85016019210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016019210&partnerID=8YFLogxK

U2 - 10.1016/j.amjms.2017.01.001

DO - 10.1016/j.amjms.2017.01.001

M3 - Article

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

ER -