Lack of association between 25(OH)D levels and incident type 2 diabetes in older women

Jennifer G. Robinson, Joann E. Manson, Joseph Larson, Simin Liu, Song Yiqing, Barbara V. Howard, Lawrence Phillips, James M. Shikany, Matthew Allison, J. David Curb, Karen Johnson, Nelson Watts

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

OBJECTIVE - To examine whether lower serum levels of serum 25-hydroxyvitamin (OH) D [25(OH)D] are associated with increased risk of developing type 2 diabetes. RESEARCH DESIGN AND METHODS - A post hoc analysis of three nested case-control studies of fractures, colon cancer, and breast cancer that measured serum 25(OH)D levels in women participating in the Women's Health Initiative (WHI) Clinical Trials and Observational Study who were free of prevalent diabetes at baseline. Diabetes was defined as self-report of physician diagnosis or receiving insulin or oral hypoglycemic medication. We used inverse probability weighting to make the study population representative of the WHI population as a whole. Weighted logistic regression models compared 25(OH)D levels (divided into quartiles, clinical cut points [<50, 50-<75, ≥75 nmol/L], or as a continuous variable) using the distribution of control subjects and adjusted for multiple confounding factors. RESULTS - Of 5,140 women (mean age 66 years) followed for an average of 7.3 years, 317 (6.2%) developed diabetes. Regardless of the cut points used or as a continuous variable, 25(OH)D levels were not associated with diabetes incidence in either age or fully adjusted models. Nor was any relationship found between 25(OH)D and incident diabetes when evaluated by strata of BMI, race/ethnicity, or randomization status in the Calcium Vitamin D trial. CONCLUSIONS - Lower serum 25(OH)D levels were not associated with increased risk of developing type 2 diabetes in this racially and ethnically diverse population of postmenopausal women.

Original languageEnglish (US)
Pages (from-to)628-634
Number of pages7
JournalDiabetes care
Volume34
Issue number3
DOIs
StatePublished - Mar 1 2011

Fingerprint

Type 2 Diabetes Mellitus
Women's Health
Serum
Logistic Models
Breast Neoplasms
Population
Random Allocation
Hypoglycemic Agents
Vitamin D
Colonic Neoplasms
Self Report
Observational Studies
25-hydroxyvitamin D
Case-Control Studies
Research Design
Clinical Trials
Insulin
Calcium
Physicians
Incidence

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Robinson, J. G., Manson, J. E., Larson, J., Liu, S., Yiqing, S., Howard, B. V., ... Watts, N. (2011). Lack of association between 25(OH)D levels and incident type 2 diabetes in older women. Diabetes care, 34(3), 628-634. https://doi.org/10.2337/dc10-1632

Lack of association between 25(OH)D levels and incident type 2 diabetes in older women. / Robinson, Jennifer G.; Manson, Joann E.; Larson, Joseph; Liu, Simin; Yiqing, Song; Howard, Barbara V.; Phillips, Lawrence; Shikany, James M.; Allison, Matthew; Curb, J. David; Johnson, Karen; Watts, Nelson.

In: Diabetes care, Vol. 34, No. 3, 01.03.2011, p. 628-634.

Research output: Contribution to journalArticle

Robinson, JG, Manson, JE, Larson, J, Liu, S, Yiqing, S, Howard, BV, Phillips, L, Shikany, JM, Allison, M, Curb, JD, Johnson, K & Watts, N 2011, 'Lack of association between 25(OH)D levels and incident type 2 diabetes in older women', Diabetes care, vol. 34, no. 3, pp. 628-634. https://doi.org/10.2337/dc10-1632
Robinson JG, Manson JE, Larson J, Liu S, Yiqing S, Howard BV et al. Lack of association between 25(OH)D levels and incident type 2 diabetes in older women. Diabetes care. 2011 Mar 1;34(3):628-634. https://doi.org/10.2337/dc10-1632
Robinson, Jennifer G. ; Manson, Joann E. ; Larson, Joseph ; Liu, Simin ; Yiqing, Song ; Howard, Barbara V. ; Phillips, Lawrence ; Shikany, James M. ; Allison, Matthew ; Curb, J. David ; Johnson, Karen ; Watts, Nelson. / Lack of association between 25(OH)D levels and incident type 2 diabetes in older women. In: Diabetes care. 2011 ; Vol. 34, No. 3. pp. 628-634.
@article{676b104825114909b79e44f8fec881e3,
title = "Lack of association between 25(OH)D levels and incident type 2 diabetes in older women",
abstract = "OBJECTIVE - To examine whether lower serum levels of serum 25-hydroxyvitamin (OH) D [25(OH)D] are associated with increased risk of developing type 2 diabetes. RESEARCH DESIGN AND METHODS - A post hoc analysis of three nested case-control studies of fractures, colon cancer, and breast cancer that measured serum 25(OH)D levels in women participating in the Women's Health Initiative (WHI) Clinical Trials and Observational Study who were free of prevalent diabetes at baseline. Diabetes was defined as self-report of physician diagnosis or receiving insulin or oral hypoglycemic medication. We used inverse probability weighting to make the study population representative of the WHI population as a whole. Weighted logistic regression models compared 25(OH)D levels (divided into quartiles, clinical cut points [<50, 50-<75, ≥75 nmol/L], or as a continuous variable) using the distribution of control subjects and adjusted for multiple confounding factors. RESULTS - Of 5,140 women (mean age 66 years) followed for an average of 7.3 years, 317 (6.2{\%}) developed diabetes. Regardless of the cut points used or as a continuous variable, 25(OH)D levels were not associated with diabetes incidence in either age or fully adjusted models. Nor was any relationship found between 25(OH)D and incident diabetes when evaluated by strata of BMI, race/ethnicity, or randomization status in the Calcium Vitamin D trial. CONCLUSIONS - Lower serum 25(OH)D levels were not associated with increased risk of developing type 2 diabetes in this racially and ethnically diverse population of postmenopausal women.",
author = "Robinson, {Jennifer G.} and Manson, {Joann E.} and Joseph Larson and Simin Liu and Song Yiqing and Howard, {Barbara V.} and Lawrence Phillips and Shikany, {James M.} and Matthew Allison and Curb, {J. David} and Karen Johnson and Nelson Watts",
year = "2011",
month = "3",
day = "1",
doi = "10.2337/dc10-1632",
language = "English (US)",
volume = "34",
pages = "628--634",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "3",

}

TY - JOUR

T1 - Lack of association between 25(OH)D levels and incident type 2 diabetes in older women

AU - Robinson, Jennifer G.

AU - Manson, Joann E.

AU - Larson, Joseph

AU - Liu, Simin

AU - Yiqing, Song

AU - Howard, Barbara V.

AU - Phillips, Lawrence

AU - Shikany, James M.

AU - Allison, Matthew

AU - Curb, J. David

AU - Johnson, Karen

AU - Watts, Nelson

PY - 2011/3/1

Y1 - 2011/3/1

N2 - OBJECTIVE - To examine whether lower serum levels of serum 25-hydroxyvitamin (OH) D [25(OH)D] are associated with increased risk of developing type 2 diabetes. RESEARCH DESIGN AND METHODS - A post hoc analysis of three nested case-control studies of fractures, colon cancer, and breast cancer that measured serum 25(OH)D levels in women participating in the Women's Health Initiative (WHI) Clinical Trials and Observational Study who were free of prevalent diabetes at baseline. Diabetes was defined as self-report of physician diagnosis or receiving insulin or oral hypoglycemic medication. We used inverse probability weighting to make the study population representative of the WHI population as a whole. Weighted logistic regression models compared 25(OH)D levels (divided into quartiles, clinical cut points [<50, 50-<75, ≥75 nmol/L], or as a continuous variable) using the distribution of control subjects and adjusted for multiple confounding factors. RESULTS - Of 5,140 women (mean age 66 years) followed for an average of 7.3 years, 317 (6.2%) developed diabetes. Regardless of the cut points used or as a continuous variable, 25(OH)D levels were not associated with diabetes incidence in either age or fully adjusted models. Nor was any relationship found between 25(OH)D and incident diabetes when evaluated by strata of BMI, race/ethnicity, or randomization status in the Calcium Vitamin D trial. CONCLUSIONS - Lower serum 25(OH)D levels were not associated with increased risk of developing type 2 diabetes in this racially and ethnically diverse population of postmenopausal women.

AB - OBJECTIVE - To examine whether lower serum levels of serum 25-hydroxyvitamin (OH) D [25(OH)D] are associated with increased risk of developing type 2 diabetes. RESEARCH DESIGN AND METHODS - A post hoc analysis of three nested case-control studies of fractures, colon cancer, and breast cancer that measured serum 25(OH)D levels in women participating in the Women's Health Initiative (WHI) Clinical Trials and Observational Study who were free of prevalent diabetes at baseline. Diabetes was defined as self-report of physician diagnosis or receiving insulin or oral hypoglycemic medication. We used inverse probability weighting to make the study population representative of the WHI population as a whole. Weighted logistic regression models compared 25(OH)D levels (divided into quartiles, clinical cut points [<50, 50-<75, ≥75 nmol/L], or as a continuous variable) using the distribution of control subjects and adjusted for multiple confounding factors. RESULTS - Of 5,140 women (mean age 66 years) followed for an average of 7.3 years, 317 (6.2%) developed diabetes. Regardless of the cut points used or as a continuous variable, 25(OH)D levels were not associated with diabetes incidence in either age or fully adjusted models. Nor was any relationship found between 25(OH)D and incident diabetes when evaluated by strata of BMI, race/ethnicity, or randomization status in the Calcium Vitamin D trial. CONCLUSIONS - Lower serum 25(OH)D levels were not associated with increased risk of developing type 2 diabetes in this racially and ethnically diverse population of postmenopausal women.

UR - http://www.scopus.com/inward/record.url?scp=79956138620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79956138620&partnerID=8YFLogxK

U2 - 10.2337/dc10-1632

DO - 10.2337/dc10-1632

M3 - Article

VL - 34

SP - 628

EP - 634

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 3

ER -