Lack of medial prefrontal cortex activation underlies the immediate extinction deficit

Seok Chan Kim, Yong Sang Jo, Il Hwan Kim, Hyun Kim, June Seek Choi

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

We conducted a series of experiments to investigate the neural basis of the immediate extinction deficit, the lack of extinction when the interval between fear memory acquisition and extinction is short. In experiment 1, rats were given extinction training composed of 15 conditioned stimuli (CSs) either 15 min (immediate extinction: I-EXT) or 24 h (delayed extinction: D-EXT) after five tone-shock pairings. In the retention test performed 48 h after conditioning, I-EXT group exhibited significantly higher freezing than D-EXT group. In experiment 2, functional activation in the medial prefrontal cortex (mPFC) was detected using c-fos immunoreactivity. The number of Fos-positive neurons in the mPFC was significantly lower in I-EXT group than in D-EXT group. In experiment 3, rats received immediate extinction with microstimulation of the infralimbic region (IL) of the mPFC, either contingently paired or unpaired with the CS. In a subsequent retention test, the paired stimulation group exhibited decreased freezing relative to the unpaired stimulation group. Together, our results suggest that the immediate extinction deficit may be linked to the lack of neuronal activity in the IL.

Original languageEnglish (US)
Pages (from-to)832-837
Number of pages6
JournalJournal of Neuroscience
Volume30
Issue number3
DOIs
StatePublished - Jan 20 2010

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Prefrontal Cortex
Freezing
Psychological Extinction
Fear
Shock
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Lack of medial prefrontal cortex activation underlies the immediate extinction deficit. / Kim, Seok Chan; Jo, Yong Sang; Kim, Il Hwan; Kim, Hyun; Choi, June Seek.

In: Journal of Neuroscience, Vol. 30, No. 3, 20.01.2010, p. 832-837.

Research output: Contribution to journalArticle

Kim, Seok Chan ; Jo, Yong Sang ; Kim, Il Hwan ; Kim, Hyun ; Choi, June Seek. / Lack of medial prefrontal cortex activation underlies the immediate extinction deficit. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 3. pp. 832-837.
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